Role of nitric oxide synthase in human sweat gland output.
Role of nitric oxide synthase in human sweat gland output.
复制标题
一氧化氮合酶在人体汗腺输出中的作用。
DOI：
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发表时间：
2020
影响因子：
3.3
通讯作者：
G. Mack
中科院分区：
文献类型：
--
作者：
G. Mack
一氧化氮合酶(NOS)抑制影响人类出汗的机制尚不清楚。我们验证了这样一种假设，即一氧化氮合酶的激活和一氧化氮的释放作用于开放K+通道和增加汗腺输出。皮内电刺激开始出汗时，用安装在皮肤上的小汗囊测量局部汗率(SR)。通过绘制SR-时间曲线下的面积与log10刺激频率的关系来绘制S形刺激-反应曲线，并归一化为对照试验中的峰值反应。仅抑制一氧化氮合酶可使出汗率峰值降低至乳酸林格组的81.5%±4.5%(p=0.0004)。50 mM TEA可降低局部SR峰值(0.317±0.060比0.511±0.104 mg·min-1·cm-2，P=0.03)。在给茶后加用L的名字，可进一步降低最大汗率反应(p=0.0145)。这些数据支持这样一种假设，即汗腺活动的运动控制是由一个功能正常的NOS系统局部调制的，该系统似乎是相加的，并且不依赖于TEA阻断K+通道的效果。
The mechanism by which nitric oxide synthase (NOS) inhibition impacts human sweating is unknow. We tested the hypothesis that the activation of NOS and release on nitric oxide acts to open K+ channels and enhance sweat gland output. Local sweat rate (SR) was measured with a small sweat capsule mounted on the skin while sweating was initiated by intradermal electrical stimulation. Sigmoid shape stimulus-response curves were generated by plotting the area under the SR-time curve versus log10 stimulus frequency and normalized to the peak response during control trials. NOS inhibition alone reduced the peak sweat rate response to 81.5 ± 4.5 % of that seen with lactated Ringers (p = 0.0004). 50 mM TEA alone reduced peak local SR (0.317 ± 0.060 versus 0.511 ± 0.104 mg • min-1 • cm-2, p = 0.03). Addition of L-NAME following TEA administration produced a further decrease in the peak sweat rate response (p = 0.0145). These data support the hypothesis that sudomotor control of sweat gland activity is locally modulated by a functioning NOS system that appears to be additive and independent to the effect of blockade of K+ channels with TEA.
小鼠爪汗腺中离子的分泌和药理反应。
DOI：
10.1042/cs0860133
发表时间：
1994
期刊：
Clinical science (London, England : 1979)
影响因子：
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作者：
Sato,K;Cavallin,S;Sato,KT;Sato,F
通讯作者：
Sato,F
影响因子：
3.3
作者：
Lee, K;Mack, GW
通讯作者：
Mack, GW