Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance.

Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance.
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DOI:
10.1038/s41409-019-0603-4
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发表时间:
2019-08
影响因子:
4.8
通讯作者:
Strober S
Strober S
中科院分区:
医学3区
文献类型:
--
作者:
Lowsky R;Strober S

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在临床前研究的基础上,在斯坦福大学医学中心对完全匹配的和单倍型匹配的患者进行了联合肾和造血细胞移植。研究的目的是诱导混合嵌合体、免疫耐受和完全停用免疫抑制药物。在大多数完全匹配的患者中实现了耐受性、持续的混合嵌合体和完全停药。目前在单倍型匹配的患者中已经实现了持续的混合嵌合体和部分停药。
Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed chimerism, immune tolerance, and complete immunosuppressive drug withdrawal. Tolerance, persistent mixed chimerism, and complete withdrawal was achieved in the majority of fully matched patients. Persistent mixed chimerism and partial withdrawal has been achieved in the haplotype matched patients at present.
DOI: 10.4049/jimmunol.169.10.5564
发表时间: 2002-11-15
影响因子: 4.4
作者:
Higuchi, M;Zeng, DF;Strober, S
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发表时间: 2000-02-27
期刊: TRANSPLANTATION
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由非致死性准备方案诱导的混合嵌合和永久特异性移植耐受。
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发表时间: 1989-02-01
影响因子: 15.3
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影响因子: 20.3
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DOI: 10.1111/ajt.12914
发表时间: 2014-11
期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子: --
作者:
Hongo D;Tang X;Baker J;Engleman EG;Strober S
通讯作者: Strober S