The Merkel cell: recent findings and unresolved problems.
The Merkel cell: recent findings and unresolved problems.
复制标题
默克尔细胞：最新发现和未解决的问题。
DOI：
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发表时间：
1995
影响因子：
--
通讯作者：
T. Tachibana
中科院分区：
文献类型：
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作者：
T. Tachibana
本文综述了最近获得的关于默克尔细胞的知识，并讨论了细胞发育和功能方面尚未解决的问题。关于其发育起源，自发现细胞角蛋白多肽后，表皮起源假说开始流行。虽然该细胞的意义尚不清楚，但可以推测其具有以下功能：1)向SAI机械感觉神经末梢释放神经递质或神经调节剂；2)对周围神经纤维的吸引和营养作用；3)刺激角质形成细胞的增殖，导致表皮胶原的三维发育；4)维持角质形成细胞的正常分化；5)生物活性物质向皮下结构的释放。这些多重功能意味着一个默克尔细胞在其生命周期中依次执行所有这些不同角色的可能性。然而，默克尔细胞也有可能由几个功能不同的亚群组成。
Recently acquired knowledge about the Merkel cell is reviewed, and unresolved problems on the development and function of the cell are discussed. Concerning its developmental origin, the epidermal origin hypothesis has become prevalent since the discovery of cytokeratin polypeptides in it. While the significance of this cell is still unclear, the following functions are presumed: 1) the release of neurotransmitters or neuromodulators to the SAI mechanosensory nerve terminals; 2) the attraction and trophic action on peripheral nerve fibers; 3) the stimulation of the proliferation of keratinocytes leading to the three-dimensional development of the epidermal anlagen; 4) the maintenance of the normal differentiation of keratinocytes; and 5) the release of bioactive substances to subepidermal structures. These multiple functions imply a possibility that one Merkel cell sequentially performs all these different roles during its life span. However, it is also possible that Merkel cells consist of several functionally different subpopulations.
影响因子：
6.5
作者：
KIM, DK;HOLBROOK, KA
通讯作者：
HOLBROOK, KA