Binocular rivalry transitions predict inattention symptom severity in adult ADHD
Binocular rivalry transitions predict inattention symptom severity in adult ADHD
复制标题
双眼竞争转变预测成人多动症注意力不集中症状的严重程度
DOI：
10.1007/s00406-017-0790-1
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发表时间：
2018
影响因子：
4.7
通讯作者：
Michael
中科院分区：
文献类型：
--
作者：
Jusyte;Zaretskaya;Natalia;Höhnle;Nina Maria;Bartels;Andreas;Schönenberg;Michael
注意力缺陷多动障碍（ADHD）是一种常见的儿童期疾病，通常会在整个发育过程中持续存在，并持续到成年期。已建立的病因学模型表明，抑制缺陷是多动症核心症状的基础。虽然运动抑制受损的实验证据是压倒性的，但人们对感觉抑制过程、它们在整个发育过程中的变化以及与多动症症状的关系知之甚少。在这里，我们使用完善的双眼竞争（BR）范式首次研究了患有多动症的成年人与视觉感知相关的抑制过程。在 BR 中，在整个观看期间，感知在两个二分视觉呈现的图像之间交替，具有较短的主导感知持续时间和较长的过渡期，表明抑制/抑制较差。通过镜面立体镜向健康对照组（N= 28）和多动症患者（N= 32）分别向每只眼睛呈现两个不同的图像（正交光栅），并要求报告他们的感知体验。各组之间的任何 BR 标记均无差异。然而，多动症组中出现了过渡持续时间和症状严重程度之间的关联。重要的是，探索性多元回归分析表明，注意力不集中症状是过渡期持续时间的唯一预测因素。成人多动症（而非儿童多动症）感觉抑制的缺失可能反映了与发育相关的代偿性变化，而抑制和注意力不集中症状之间的相关性可能揭示了该疾病的不变核心。
Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibition is overwhelming, little is known about the sensory inhibition processes, their changes throughout the development, and the relationship to ADHD symptoms. Here, we used the well-established binocular rivalry (BR) paradigm to investigate for the very first time the inhibitory processes related to visual perception in adults with ADHD. In BR, perception alternates between two dichoptically presented images throughout the viewing period, with shorter dominant percept durations and longer transition periods indicating poorer suppression/inhibition. Healthy controls (N= 28) and patients with ADHD (N= 32) were presented with two dissimilar images (orthogonal gratings) separately to each eye through a mirror stereoscope and asked to report their perceptual experiences. There were no differences between groups in any of the BR markers. However, an association between transition durations and symptom severity emerged in the ADHD group. Importantly, an exploratory multiple regression analysis revealed that inattention symptoms were the sole predictor for the duration of transition periods. The lack of impairments to sensory inhibition in adult, but not pediatric ADHD may reflect compensatory changes associated with development, while a correlation between inhibition and inattention symptoms may reveal an invariant core of the disorder.
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DOI：
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发表时间：
2002
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Der Nervenarzt
影响因子：
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