Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope.
Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope.
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DOI：
10.1186/s40798-023-00573-9
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发表时间：
2023-05-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
运动对整个身体都有公认的有益效果。以前的研究表明，运动可以促进各种器官的组织再生和修复。本文综述了运动对骨骼肌、神经系统和血管系统中干细胞和祖细胞介导的组织再生的主要影响。本文还详细讨论了运动诱导的干细胞活化在病理条件下和不同器官衰老中的保护作用。此外，我们还描述了运动诱导组织再生的主要分子机制，包括生长因子、信号通路、氧化应激、代谢因子和非编码RNA的作用。我们还总结了针对运动诱导组织再生的关键信号通路和分子的治疗方法，如IGF 1，PI 3 K和microRNA。总的来说，对运动诱导的组织再生的全面了解将有助于发现新的药物靶点和治疗策略。运动对骨骼、肌肉、血管和神经系统再生的保护作用依赖于运动诱导的干细胞/祖细胞活化。细胞凋亡促进的干细胞活化可归因于多种因素，如信号传导途径、氧化应激、代谢因子和非编码RNA。从药理学上靶向运动诱导的干细胞活化的关键调节因子已显示出治疗潜力。
Exercise has well-recognized beneficial effects on the whole body. Previous studies suggest that exercise could promote tissue regeneration and repair in various organs. In this review, we have summarized the major effects of exercise on tissue regeneration primarily mediated by stem cells and progenitor cells in skeletal muscle, nervous system, and vascular system. The protective function of exercise-induced stem cell activation under pathological conditions and aging in different organs have also been discussed in detail. Moreover, we have described the primary molecular mechanisms involved in exercise-induced tissue regeneration, including the roles of growth factors, signaling pathways, oxidative stress, metabolic factors, and non-coding RNAs. We have also summarized therapeutic approaches that target crucial signaling pathways and molecules responsible for exercise-induced tissue regeneration, such as IGF1, PI3K, and microRNAs. Collectively, the comprehensive understanding of exercise-induced tissue regeneration will facilitate the discovery of novel drug targets and therapeutic strategies. The protective effect of exercise on the regeneration of skeletal, muscular, vascular, and nervous system depends on exercise-induced stem cell/progenitor cell activation. Exercise-promoted stem cell activation could be attributed to several factors such as signaling pathways, oxidative stress, metabolic factors, and non-coding RNAs. Pharmacologically targeting the key regulators of exercise-induced stem cell activation has shown therapeutic potential.
影响因子：
5
作者：
Ryall, Karen A.;Bezzerides, Vassilios J.;Rosenzweig, Anthony;Saucerman, Jeffrey J.
通讯作者：
Saucerman, Jeffrey J.
靶向细胞外DNA，以将IGF-1输送到受伤的心脏。
影响因子：
4.6
作者：
Khan RS;Martinez MD;Sy JC;Pendergrass KD;Che PL;Brown ME;Cabigas EB;Dasari M;Murthy N;Davis ME
通讯作者：
Davis ME