Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke.
Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke.
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DOI：
10.1371/journal.pone.0163731
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Peng H
中科院分区：
文献类型：
--
作者：
Hu W;Chen S;Song Y;Zhu F;Shi J;Han X;Zhou D;Zhi Z;Zhang F;Shen Y;Ma J;Liu CF;Peng H
血清可溶性corin与中风有关。但其是否与脑卒中预后相关尚未研究。因此，我们旨在研究血清可溶性corin与卒中后3个月内不良结局风险的关系。我们对522名中风患者进行了为期3个月的随访，以确定主要残疾、死亡和血管事件。所有参与者在基线时测量血清可溶性corin。采用Logistic回归分析研究基线血清可溶性corin与卒中结局的相关性，校正年龄、性别、基线NIHSS评分、发病至住院时间、吸烟、饮酒、高血压、糖尿病、冠心病、房颤、卒中家族史和卒中亚型。高corin患者的主要残疾或死亡复合结局的粗风险（OR = 0.64，95%CI：0.43-0.96）显著低于低corin患者（最低三分位数）。校正年龄和基线NIHSS评分后，corin水平高的患者发生严重残疾或死亡的复合结局的风险仍显著较低（OR = 0.60，95%CI：0.36-0.99）。在额外调整其他常规因素后，这种关联变得底线显著（OR = 0.61，P = 0.058）。血清可溶性corin与其他复合结局之间无相关性。血清可溶性corin缺乏可预测卒中后3个月内严重残疾的风险，与基线神经功能缺损无关。我们的研究结果可能表明corin在卒中预后中的可能作用。
Serum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke. We followed 522 stroke patients for 3 months to identify major disability, death and vascular events. Serum soluble corin was measured at baseline for all participants. Logistic regression was used to examine the associations of baseline serum soluble corin with outcomes of stroke, adjusting for age, sex, baseline NIHSS score, hours from onset to hospitalization, smoking, drinking, hypertension, diabetes, coronary heart disease, atrial fibrillation, family history of stroke, and stroke subtype. Patients with high corin had a significantly lower crude risk for the composite outcome of major disability or death (OR = 0.64, 95%CI: 0.43–0.96) than patients with low corin (the lowest tertile). After adjustment for age and baseline NIHSS score, patients with high corin still had a significantly lower risk for the composite outcome of major disability or death (OR = 0.60, 95%CI: 0.36–0.99). This association became bottom line significant after additionally adjusting for other conventional factors (OR = 0.61, P = 0.058). No association was found between serum soluble corin and other composite outcomes. Serum soluble corin deficiency predicted risk for major disability within 3 months after stroke, independent of baseline neurological deficient. Our results may indicate a probable role of corin in stroke prognosis.
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