Natural History of T1N0M0 Hepatocellular Carcinoma: Large-Scale Study in the United States.
Natural History of T1N0M0 Hepatocellular Carcinoma: Large-Scale Study in the United States.
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作者：
Al-Shamsi HO;Abdel-Wahab R;Hassan MM;Shalaby AS;Dahbour I;Lacin S;Mahvash A;Odisio BC;Murthy R;Avritscher R;Abdelsalam ME;Rashid A;Vauthey JN;Aloia TA;Conrad C;Chun YS;Krishnan S;Das P;Koay EJ;Amin HM;Yao JC;Kaseb AO
肝细胞癌（HCC）的预后取决于临床病理特征和所提供的治疗。我们的目的是评估在20年期间接受不同治疗的TNM期HCC肿瘤的自然史。1992年至2011年间，共纳入397例I期HCC患者。详细信息从MD安德森癌症中心患者的医疗记录中检索。采用Kaplan-Meier法计算患者总生存期（OS）。采用Cox回归分析计算不同预后因素的估计风险比（HR）和95%可信区间（CI）。在397例患者中，67.5%为男性，42.8%为肝炎相关HCC， 59.7%为肝硬化。在校正混杂因素后，我们发现所有治疗方式均与死亡率显著降低相关，手术、消融、局部和全身治疗患者的总生存期分别为63,42.03,34.3和22.1个月。对肝硬化和非肝硬化患者的限制性分析显示，与全身治疗相比，消融和局部治疗与更长的生存期显著相关。不论何种治疗方式，TNM期HCC患者预后良好。值得注意的是，与全身治疗相比，消融和局部治疗显著改善了OS。
Hepatocellular carcinoma (HCC) Prognosis is depending on clinicopathological features in addition to treatment provided. We aimed to assess the natural history of TNM stage I HCC tumors which received different treatment over a period of twenty years. Between 1992 till 2011 a total of 397 stage I HCC patients were included. Detailed information were retrieved from MD Anderson Cancer Center patients’ medical records. Kaplan-Meier method was used to calculate Patients’ overall survival (OS). Cox regression analysis was used to calculate the estimate hazard ratio (HR) and 95% confidence interval (CI) of different prognostic factors. Out of 397 patients, we have 67.5% males, 42.8% hepatitis related HCC, and 59.7% have underlying cirrhosis. After adjustment for confounding factors we found that all therapeutic modalities associated with significant mortality rate reduction with overall survival of 63, 42.03, 34.3, 22.1 months among patients treated with surgery, ablation, local, and systemic therapy respectively. Restricted analysis among cirrhotic and non-cirrhotic patients showed that ablative and local therapy significantly associated with longer OS compared to systemic therapy. TNM Stage I HCC patients have favorable prognosis regardless of the type of treatment. Notably, ablative and local therapy significantly improved OS compared to systemic therapy.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
DOI：
10.1111/j.1478-3231.2008.01957.x
发表时间：
2009-04
期刊：
Liver international : official journal of the International Association for the Study of the Liver
影响因子：
--
作者：
Tandon P;Garcia-Tsao G
通讯作者：
Garcia-Tsao G
影响因子：
158.5
作者：
Llovet, Josep M.;Ricci, Sergio;Bruix, Jordi
通讯作者：
Bruix, Jordi
DOI：
10.1016/j.jamcollsurg.2007.03.002
发表时间：
2007-07-01
影响因子：
5.2
作者：
Lang, Hauke;Sotiropoulos, Georgios C.;Broelsch, Christoph E.
通讯作者：
Broelsch, Christoph E.
影响因子：
8.4
作者：
通讯作者：
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