Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer.
Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer.
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DOI：
10.1186/bcr449
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Nawaz Z
中科院分区：
文献类型：
--
作者：
Gao X;Nawaz Z
Progesterone, an ovarian steroid hormone, plays a key role in the development and function of the mammary gland, as it also does in the uterus and the ovary. The action of progesterone is mediated through its intracellular cognate receptor, the progesterone receptor (PR), which functions as a transcription factor that regulates gene expression. As with other nuclear receptors, coregulators (coactivators and corepressors) recruited by the liganded or unliganded PR, either to enhance or to suppress transcription activity, modulate the function of the PR. Mutation or aberrant expression of the coregulators might thus affect the normal function of the PR and hence disrupt the normal development of the mammary gland, which may lead to breast cancer.
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影响因子：
4.8
作者：
Brady, ME;Ozanne, DM;Robson, CN
通讯作者：
Robson, CN
DOI：
10.1016/s1071-5576(99)00062-3
发表时间：
2000-01-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Conneely, OM;Lydon, JP;O'Malley, BW
通讯作者：
O'Malley, BW
影响因子：
3.8
作者：
Sivaraman, L;Nawaz, Z;O'Malley, BW
通讯作者：
O'Malley, BW
影响因子：
4.8
作者：
Giangrande, PH;Pollio, G;McDonnell, DP
通讯作者：
McDonnell, DP
影响因子：
--
作者：
Jackson, TA;Richer, JK;Horwitz, KB
通讯作者：
Horwitz, KB