Effects of dietary restriction on neuroinflammation in neurodegenerative diseases.
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases.
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DOI：
10.1084/jem.20190086
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Piccio L
中科院分区：
文献类型：
--
作者：
Fontana L;Ghezzi L;Cross AH;Piccio L
饮食是全身和中枢神经系统炎症的重要调节剂，对新陈代谢、免疫和肠道微生物组具有深远的影响。丰塔纳等人。讨论关于卡路里摄入量与神经炎症和神经变性机制之间关系的最新发现。最近对实验动物模型和人类的不断积累的研究表明，饮食在调节神经炎症和神经退行性机制（导致一些最常见的慢性中枢神经系统（CNS）疾病）方面比以前认为的更普遍和显着的作用。慢性或间歇性食物限制对大脑和外周代谢、免疫和肠道微生物组生物学的塑造具有深远的影响。热量摄入、进餐频率、饮食质量和肠道微生物组之间的相互作用调节特定的代谢和分子途径，从而调节正常大脑衰老和中枢神经系统神经退行性疾病（包括阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和多发性硬化症等）期间的细胞、组织和器官稳态以及炎症。本综述讨论了这些发现及其在预防和治疗中枢神经系统神经炎症疾病以及促进大脑健康老化方面的潜在应用。
Diet is an important modulator of systemic and central nervous system inflammation, with profound effects in metabolism, immunity, and the gut microbiome. Fontana et al. discuss recent findings on the relationship between calorie intake and the mechanisms underlying neuroinflammation and neurodegeneration. Recent and accumulating work in experimental animal models and humans shows that diet has a much more pervasive and prominent role than previously thought in modulating neuroinflammatory and neurodegenerative mechanisms leading to some of the most common chronic central nervous system (CNS) diseases. Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, among others. This review discusses these findings and their potential application to the prevention and treatment of CNS neuroinflammatory diseases and the promotion of healthy brain aging.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
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作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
3.9
作者：
Chinta, Shankar J.;Woods, Georgia;Andersen, Julie K.
通讯作者：
Andersen, Julie K.
DOI：
10.1093/gerona/50a.6.b337
发表时间：
1995-11-01
影响因子：
5.1
作者：
CEFALU, WT;BELLFARROW, AD;THORPE, SR
通讯作者：
THORPE, SR
影响因子：
29
作者：
Cignarella F;Cantoni C;Ghezzi L;Salter A;Dorsett Y;Chen L;Phillips D;Weinstock GM;Fontana L;Cross AH;Zhou Y;Piccio L
通讯作者：
Piccio L