Rapid feedback processing in human nucleus accumbens and motor thalamus
Rapid feedback processing in human nucleus accumbens and motor thalamus
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人类伏隔核和运动丘脑的快速反馈处理
DOI：
10.1016/j.neuropsychologia.2015.02.032
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发表时间：
2015
期刊：
影响因子：
2.6
通讯作者：
Jocham G
中科院分区：
文献类型：
--
作者：
Schüller T;Gruendler TOJ;Jocham G
丘脑和脑桥核是反馈加工模型中不可或缺的部分。脑深部电刺激（DBS）已成功用于缓解精神疾病的症状，包括强迫症（OCD）和图雷特综合征（TS）。反馈相关负波（FRN）是反映后内侧额叶皮层（pMFC）活动的事件相关电位，与反馈加工有关。在这里，我们报告了三种情况下，我们记录了头皮脑电图和局部场电位（LFP）从外部电极位于NAcc或丘脑（VA/VL），而患者从事修改后的时间估计任务，已知从事反馈处理，并引发FRN。此外，29名健康参与者（HP）在同一任务中记录了头皮EEG，所有结构（pMFC，NAcc和丘脑）的信号受到正反馈和负反馈的不同调制。在FRN时间间隔内，NAcc中的LFP活性在正反馈后显示出双相时程。负面反馈引起了更弱和更晚的反应。在丘脑中，在FRN时间间隔期间记录到单相调制。同样，这种调制更明显的积极的性能反馈后相比，负反馈。在目标区域外的通道中，未观察到调制。表面FRN可靠地引起了一组水平在HP和患者和HP之间的负反馈后没有显着差异。德国临床试验注册：神经认知功能障碍的规范内基底神经节-皮质环和他们的治疗调制通过脑深部电刺激强迫症和抽动秽语综合征患者，http://www.drks.de/DRKS00005316。
The nucleus accumbens (NAcc) and thalamus are integral parts in models of feedback processing. Deep brain stimulation (DBS) has been successfully employed to alleviate symptoms of psychiatric conditions including obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). Common target structures are the NAcc and the ventral anterior and ventro-lateral nuclei (VA/VL) of the thalamus, for OCD and TS, respectively.The feedback related negativity (FRN) is an event-related potential associated with feedback processing reflecting posterior medial frontal cortex (pMFC) activity. Here we report on three cases where we recorded scalp EEG and local field potentials (LFP) from externalized electrodes located in the NAcc or thalamus (VA/VL) while patients engaged in a modified time estimation task, known to engage feedback processing and elicit the FRN. Additionally, scalp EEG were recorded from 29 healthy participants (HP) engaged in the same task.The signal in all structures (pMFC, NAcc, and thalamus) was differently modulated by positive and negative feedback. LFP activity in the NAcc showed a biphasic time course after positive feedback during the FRN time interval. Negative feedback elicited a much weaker and later response. In the thalamus a monophasic modulation was recorded during the FRN time interval. Again, this modulation was more pronounced after positive performance feedback compared to negative feedback. In channels outside the target area no modulation was observed. The surface-FRN was reliably elicited on a group level in HP and showed no significant difference following negative feedback between patients and HP.German Clinical Trial Register: Neurocognitive specification of dysfunctions within basal ganglia-cortex loops and their therapeutic modulation by deep brain stimulation in patients with obsessive compulsive disorder and Tourette syndrome, http://www.drks.de/DRKS00005316.
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影响因子：
5.4
作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen
通讯作者：
M. Botvinick;T. Braver;D. Barch;C. Carter;J. Cohen
影响因子：
10.6
作者：
Huys, Daniel;Bartsch, Christina;Kuhn, Jens
通讯作者：
Kuhn, Jens
影响因子：
33.6
作者：
M. Ullsperger;C. Danielmeier;G. Jocham
通讯作者：
M. Ullsperger;C. Danielmeier;G. Jocham
影响因子：
5.3
作者：
Seifert, Sebastian;von Cramon, D. Yves;Ullsperger, Markus
通讯作者：
Ullsperger, Markus
伏核活动分离不同形式的显着性：来自人类颅内记录的证据
DOI：
10.1523/jneurosci.5276-12.2013
发表时间：
2013
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
Zaehle T;Bauch EM;Hinrichs H;Schmitt FC;Voges J;Heinze HJ;Bunzeck N
通讯作者：
Bunzeck N