Functional subgroups of cochlear inner hair cell ribbon synapses differently modulate their EPSC properties in response to stimulation.
Functional subgroups of cochlear inner hair cell ribbon synapses differently modulate their EPSC properties in response to stimulation.
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DOI：
10.1152/jn.00452.2020
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发表时间：
2021-06-01
影响因子：
2.5
通讯作者：
Ricci AJ
中科院分区：
文献类型：
--
作者：
Niwa M;Young ED;Glowatzki E;Ricci AJ
Spiral ganglion neurons (SGNs) form single synapses on inner hair cells (IHCs), transforming sound-induced IHC receptor potentials into trains of action potentials. SGN neurons are classified by spontaneous firing rates as well as their threshold response to sound intensity levels. We investigated the hypothesis that synaptic specializations underlie mouse SGN response properties and vary with pillar versus modiloar synapse location around the hair cell. Depolarizing hair cells with 40 mM K+ increased the rate of postsynaptic responses. Pillar synapses matured later than modiolar synapses. Excitatory postsynaptic current (EPSC) amplitude, area, and number of underlying events per EPSC were similar between synapse locations at steady state. However, modiolar synapses produced larger monophasic EPSCs when EPSC rates were low and EPSCs became more multiphasic and smaller in amplitude when rates were higher, while pillar synapses produced more monophasic and larger EPSCs when the release rates were higher. We propose that pillar and modiolar synapses have different operating points. Our data provide insight into underlying mechanisms regulating EPSC generation. NEW & NOTEWORTHY Data presented here provide the first direct functional evidence of late synaptic maturation of the hair cell- spiral ganglion neuron synapse, where pillar synapses mature after postnatal day 20. Data identify a presynaptic difference in release during stimulation. This difference may in part drive afferent firing properties.
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DOI：
10.1523/jneurosci.1866-11.2011
发表时间：
2011-11-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Graydon CW;Cho S;Li GL;Kachar B;von Gersdorff H
通讯作者：
von Gersdorff H
影响因子：
2.8
作者：
LIBERMAN, MC
通讯作者：
LIBERMAN, MC
影响因子：
5.3
作者：
Chen, Minghui;von Gersdorff, Henrique
通讯作者：
von Gersdorff, Henrique
影响因子：
2.8
作者：
Liberman, Leslie D.;Liberman, M. Charles
通讯作者：
Liberman, M. Charles
DOI：
10.1523/jneurosci.4439-09.2010
发表时间：
2010-03-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Grant L;Yi E;Glowatzki E
通讯作者：
Glowatzki E