Zebrafish as a model system for environmental health studies in the grade 9-12 classroom.
Zebrafish as a model system for environmental health studies in the grade 9-12 classroom.
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斑马鱼作为 9-12 年级课堂环境健康研究的模型系统。
DOI：
10.1089/zeb.2013.0881
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发表时间：
2014
期刊：
影响因子：
2
通讯作者：
Petering,DavidH
中科院分区：
文献类型：
--
作者：
Tomasiewicz,HenryG;Hesselbach,Renee;Carvan,MichaelJohn;Goldberg,Barbara;Berg,CraigA;Petering,DavidH
正在发育的斑马鱼胚胎被用作高中学生进行科学调查的模型系统，揭示正常发育的特征，并测试不同的环境毒物如何影响发育过程。该单元的主要目标是让来自各种社会经济背景的学生参与探究式学习和动手实验，特别关注服务不足的市中心高中。此外，该模块还为教师和学生提供了一个平台，以设计更多的基于探究的实验。在这个模块中，学生们产卵成年斑马鱼产生发育中的胚胎，将胚胎暴露于各种有毒物质，然后收集和分析从对照和实验胚胎中获得的数据。该模块为学生提供了一个灵活的实验框架，以测试许多环境毒物，如乙醇，咖啡因和尼古丁对脊椎动物模型生物体发育的影响。学生们还观察了剂量对实验结果的影响。通过观察化学物质对脊椎动物胚胎的影响，学生们得出了这些化学物质如何影响人类发育和健康的结论。参与学生完成的预测试和后测试结果表明，人们对环境因子对鱼类和人类影响的认识在统计上发生了显着变化。此外，该计划的评估人员得出结论，参与该模块导致学生的态度发生了显着变化。和教师对一般科学，特别是环境健康的态度。
Developing zebrafish embryos were used as a model system for high school students to conduct scientific investigations that reveal features of normal development and to test how different environmental toxicants impact the developmental process. The primary goal of the module was to engage students from a wide range of socio-economic backgrounds, with particular focus on underserved inner-city high schools, in inquiry-based learning and hands-on experimentation. In addition, the module served as a platform for both teachers and students to design additional inquiry-based experiments. In this module, students spawned adult zebrafish to generate developing embryos, exposed the embryos to various toxicants, then gathered, and analyzed data obtained from control and experimental embryos. The module provided a flexible, experimental framework for students to test the effects of numerous environmental toxicants, such as ethanol, caffeine, and nicotine, on the development of a model vertebrate organism. Students also observed the effects of dose on experimental outcomes. From observations of the effects of the chemical agents on vertebrate embryos, students drew conclusions on how these chemicals could impact human development and health. Results of pre-tests and post-tests completed by participating students indicate statistically significant changes in awareness of the impact of environmental agents on fish and human beings In addition, the program's evaluator concluded that participation in the module resulted in significant changes in the attitude of students and teachers toward science in general and environmental health in particular.
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