Quality assurance device for four-dimensional IMRT or SBRT and respiratory gating using patient-specific intrafraction motion kernels.
Quality assurance device for four-dimensional IMRT or SBRT and respiratory gating using patient-specific intrafraction motion kernels.
复制标题
DOI：
10.1120/jacmp.v8i4.2683
复制
发表时间：
2007-09-17
影响因子：
2.1
通讯作者：
Tomé WA
中科院分区：
文献类型：
--
作者：
Nelms BE;Ehler E;Bragg H;Tomé WA
将内核转换为光束特定的二维 (2D) 运动“投影”，实时预览运动，并驱动精密 X-Y 电动设备，该设备顶部安装有平面 IMRT QA 测量设备。四维计算机断层扫描 (4D CT) 和植入信标等新兴技术预计将使临床医生能够准确模拟分次内运动，并定量估计涉及移动目标的放射治疗的内部目标体积 (ITV)。在调强 (IMRT) 和立体定向身体放射治疗 (SBRT) 实施情况下，临床医生必须考虑调制的时间性质与 ITV 内目标运动之间的相互作用。需要一种 4D IMRT/SBRT 质量保证 (QA) 设备，该设备可以合并并分析与剂量输送和呼吸门控相关的定制分次内运动。我们构建了一个 4D IMRT/SBRT 原型设备，并将表示运动内核的 (X, Y, Z)(T) 坐标输入到软件应用程序中，在呼吸周期的任何单相的光束视野中与目标相交的探测器（所有探测器的一小部分）被定义为“目标探测器”，以分析多个分数之间的剂量均匀性。最近发布了有关使用该设备来量化靶点运动（针对多种输送方式以及有或没有门控）引起的剂量变化的数据。用于患者定制 4D IMRT/SBRT QA 的软件和硬件组合解决方案是评估分次内运动条件下 IMRT 输送的有效工具。 4D IMRT QA 设备准确地再现了所有光束眼视图运动内核的投影运动内核。该设备已被证明能够： • 有效地量化静态规划目标体积内移动目标导致的剂量均匀性下降，以及 • 与商用呼吸门控系统集成，以确保系统有效工作。这种装置被认为是优化门控占空比的潜在工具，以最大限度地提高输送效率，同时最大限度地减少剂量变异性。 PACS 编号：87.50.Gi、87.53.Dq、87.53.Kn、87.53.Mr、87.53.Tf、87.56.Fc、87.58.Sp
transformed the kernel into beam‐specific two‐dimensional (2D) motion “projections,” previewed the motion in real time, and drove a precision X–Y motorized device that had, atop it, a mounted planar IMRT QA measurement device. Emerging technologies such as four‐dimensional computed tomography (4D CT) and implanted beacons are expected to allow clinicians to accurately model intrafraction motion and to quantitatively estimate internal target volumes (ITVs) for radiation therapy involving moving targets. In the case of intensity‐modulated (IMRT) and stereotactic body radiation therapy (SBRT) delivery, clinicians must consider the interplay between the temporal nature of the modulation and the target motion within the ITV. A need exists for a 4D IMRT/SBRT quality assurance (QA) device that can incorporate and analyze customized intrafraction motion as it relates to dose delivery and respiratory gating. We built a 4D IMRT/SBRT prototype device and entered (X, Y, Z)(T) coordinates representing a motion kernel into a software application that The detectors that intersected the target in the beam's‐eye‐view of any single phase of the breathing cycle (a small subset of all the detectors) were defined as “target detectors” to be analyzed for dose uniformity between multiple fractions. Data regarding the use of this device to quantify dose variation fraction‐to‐fraction resulting from target motion (for several delivery modalities and with and without gating) have been recently published. A combined software and hardware solution for patient‐customized 4D IMRT/ SBRT QA is an effective tool for assessing IMRT delivery under conditions of intrafraction motion. The 4D IMRT QA device accurately reproduced the projected motion kernels for all beam's‐eye‐view motion kernels. This device has been proved to • effectively quantify the degradation in dose uniformity resulting from a moving target within a static planning target volume, and • integrate with a commercial respiratory gating system to ensure that the system is working effectively. Such a device is discussed as a potential tool to optimize the gating duty cycle to maximize delivery efficiency while minimizing dose variability. PACS numbers: 87.50.Gi, 87.53.Dq, 87.53.Kn, 87.53.Mr, 87.53.Tf, 87.56.Fc, 87.58.Sp
登录
查看更多内容
影响因子：
3.1
作者：
Hodge, Wes;Tome, Wolfgang A.;Mehta, Minesh P.
通讯作者：
Mehta, Minesh P.
影响因子：
5.7
作者：
Ehler, Eric D.;Nelms, Benjamin E.;Tome, Wolfgang A.
通讯作者：
Tome, Wolfgang A.
影响因子：
3.8
作者：
Jursinic, PA;Nelms, BE
通讯作者：
Nelms, BE
影响因子：
3.8
作者：
Li, XA;Stepaniak, C;Gore, E
通讯作者：
Gore, E
影响因子：
3.8
作者：
Zhang, TZ;Orton, NP;Tomé, WA
通讯作者：
Tomé, WA