Cytokine Signatures for Lung Cancer Diagnosis in African American Populations.
Cytokine Signatures for Lung Cancer Diagnosis in African American Populations.
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DOI：
10.3390/jpm14010117
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发表时间：
2024-01-20
影响因子：
--
通讯作者：
Jiang, Feng
中科院分区：
文献类型：
--
作者：
Leng, Qixin;Dhilipkannah, Pushpa;Jiang, Feng
肺癌是主要的癌症死亡，不成比例地影响非洲裔美国人（AAs），他们的发病率和死亡率高于其他种族群体。细胞因子在癌症发展中起着至关重要的作用。在104名肺癌患者和48名对照中仔细检查了8种关键细胞因子。在AA和白色美国人（WA）肺癌病例中，IL-8、IFN-γ和TNF-α水平均升高。IL-10和MCP-1在AA肺癌患者中表现出明显的升高，MCP-1与肺腺癌相关。IL-6水平在WA肺癌患者中特异性升高，并与肺腺癌相关。特异性细胞因子的联合使用显示出诊断肺癌的前景，IL-8、IL-10和MCP-1在AA中实现76%的灵敏度和79%的特异性，IL-6和IL-8联合在WA中提供76%的灵敏度和74%的特异性。这些诊断生物标志物在58例病例和58例对照的独立队列中得到验证。这些种族相关的细胞因子生物标志物具有早期检测和解决肺癌结果差异的潜力。肺癌是男性和女性癌症相关死亡的主要原因。与其他种族群体相比，非洲裔美国人（AAs）的发病率和死亡率不成比例地高。细胞因子在癌症的发生、发展和扩散中起着多方面的关键作用。我们的目的是确定细胞因子的生物标志物，用于早期检测AAs中的肺癌。我们使用Fireflux免疫测定法检测了104例肺癌患者和48例无癌个体血浆中的8种关键细胞因子（白细胞介素-1，IL-6，IL-8，IL-10，IL-12 p70，单核细胞趋化蛋白-1（MCP-1），干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α））。这些发现随后在58例病例和58例对照的单独队列中得到验证。IL-8、IFN-γ和TNF-α在AA和白色美国人（WA）肺癌病例中均表现出升高的水平。值得注意的是，IL-10和MCP-1在AA肺癌患者中特异性地显示出显著增加，MCP-1水平与肺腺癌病例相关。相反，WA肺癌患者表现出升高的IL-6水平，特别是与肺腺癌相关。特异性细胞因子的联合使用在肺癌诊断中显示出希望，IL-8、IL-10和MCP-1在AA中达到76%的灵敏度和79%的特异性，IL-6和IL-8联合在WA中提供76%的灵敏度和74%的特异性。这些诊断性生物标志物在独立队列中得到验证。种族相关的细胞因子生物标志物有望诊断AA和WA中的肺癌，可能解决观察到的种族差异。
Lung cancer is the primary cancer fatality, disproportionately affecting African Americans (AAs), who experience higher incidence and mortality rates than other ethnic groups. Cytokines play crucial roles in cancer development. Eight key cytokines were scrutinized in 104 lung cancer patients and 48 controls. The levels of IL-8, IFN-γ, and TNF-α were elevated in both AA and White American (WA) lung cancer cases. IL-10 and MCP-1 exhibited pronounced elevation specifically in AA lung cancer patients, with MCP-1 being associated with lung adenocarcinoma. IL-6 levels were specifically elevated in WA lung cancer patients and associated with lung adenocarcinoma. The combined use of specific cytokines showed promise in diagnosing lung cancer, with IL-8, IL-10, and MCP-1 achieving 76% sensitivity and 79% specificity in AAs, and IL-6 and IL-8 combined offering 76% sensitivity and 74% specificity in WAs. These diagnostic biomarkers were validated in an independent cohort of 58 cases and 58 controls. These ethnicity-related cytokine biomarkers hold potential for early detection and addressing disparities in lung cancer outcomes. Lung cancer is the leading cause of cancer-related deaths among both men and women. African Americans (AAs) experience disproportionately higher incidence and mortality compared to other ethnic groups. Cytokines play multifaceted and crucial roles in the initiation, progression, and spread of cancer. Our aim was to identify cytokine biomarkers for the early detection of lung cancer in AAs. We examined eight key cytokines (Interleukin-1, IL-6, IL-8, IL-10, IL-12p70, monocyte chemotactic protein-1 (MCP-1), interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α)) in the plasma of 104 lung cancer patients and 48 cancer-free individuals using the FirePlex Immunoassay. These findings were subsequently validated in a separate cohort of 58 cases and 58 controls. IL-8, IFN-γ, and TNF-α exhibited elevated levels in both AA and White American (WA) lung cancer cases. Notably, IL-10 and MCP-1 displayed significant increases specifically in AA lung cancer patients, with MCP-1 levels associated with lung adenocarcinoma cases. Conversely, WA lung cancer patients showed heightened IL-6 levels, particularly linked to lung adenocarcinoma. The combined use of specific cytokines showed promise in lung cancer diagnosis, with IL-8, IL-10, and MCP-1 achieving 76% sensitivity and 79% specificity in AAs and IL-6 and IL-8 combined offering 76% sensitivity and 74% specificity in WAs. These diagnostic biomarkers were validated in the independent cohort. The ethnicity-related cytokine biomarkers hold promise for diagnosing lung cancer in AAs and WAs, potentially addressing the observed racial disparity.
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DOI：
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发表时间：
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期刊：
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