Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.M500067-JLR200
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.M500067-JLR200
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大豆蛋白降低高胰岛素肥胖 Zucker fa/fa 大鼠的肝脂毒性 出版，JLR Papers in Press，2005 年 7 月 1 日。DOI 10.1194/jlr.M500067-JLR200
DOI：
10.1194/jlr.m500067-jlr200
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发表时间：
2005
影响因子：
6.5
通讯作者：
N. Torres
中科院分区：
文献类型：
--
作者：
A. Tovar;Iván Torre;Melissa K. Ochoa;A. Elias;V. Ortíz;C. Aguilar;N. Torres
肝脏脂肪变性通常存在于胰岛素抵抗的发展过程中，它是部分归因于加速脂肪生成的脂毒性的明显体征。有证据表明，大豆蛋白饮食可以防止肝固醇调节元件结合蛋白-1（SREBP-1）的过度表达，减少脂质积累。因此，本工作的目的是研究大豆蛋白饮食是否可以通过调节参与高胰岛素血症和高瘦素血症Zucker肥胖fa/fa大鼠脂质代谢的转录因子来预防脂肪肝的发生。血清和肝脏胆固醇和甘油三酯水平，以及极低密度脂蛋白-甘油三酯和低密度脂蛋白-胆固醇，显着低于大鼠喂养大豆蛋白比大鼠酪蛋白饮食160天。肝脏胆固醇的降低与肝脏X受体-α及其靶基因7-α羟化酶和ABCA 1的低表达相关。大豆蛋白还降低了SREBP-1及其几个靶基因FAS、硬脂酰辅酶A去饱和酶-1以及Δ5和Δ6去饱和酶的表达，即使在高胰岛素血症的情况下也能降低脂肪生成。SREBP-1的减少与大豆异黄酮的存在无关。最后，大豆蛋白降低脂肪细胞中的SREBP-1表达，防止肥大，这也有助于防止肝脏脂毒性的发展。
Hepatic steatosis is commonly present during the development of insulin resistance, and it is a clear sign of lipotoxicity attributable in part to an accelerated lipogenesis. There is evidence that a soy protein diet prevents the overexpression of hepatic sterol-regulatory element binding protein-1 (SREBP-1), decreasing lipid accumulation. Therefore, the aim of the present work was to study whether a soy protein diet may prevent the development of fatty liver through the regulation of transcription factors involved in lipid metabolism in hyperinsulinemic and hyperleptinemic Zucker obese fa/fa rats. Serum and hepatic cholesterol and triglyceride levels, as well as VLDL-triglyceride and LDL-cholesterol, were significantly lower in rats fed soy protein than in rats fed a casein diet for 160 days. The reduction in hepatic cholesterol was associated with a low expression of liver X receptor-α and its target genes, 7-α hydroxylase and ABCA1. Soy protein also decreased the expression of SREBP-1 and several of its target genes, FAS, stearoyl-CoA desaturase-1, and Δ5 and Δ6 desaturases, decreasing lipogenesis even in the presence of hyperinsulinemia. Reduction in SREBP-1 was not associated with the presence of soy isoflavones. Finally, soy protein reduced SREBP-1 expression in adipocytes, preventing hypertrophy, which also helps prevent the development of hepatic lipotoxicity.
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DOI：
--
发表时间：
2002
期刊：
The Journal of biological chemistry
影响因子：
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作者：
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J. Repa;K. Berge;Chris Pomajzl;J. Richardson;H. Hobbs;D. Mangelsdorf
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影响因子：
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Shimano, H;Horton, JD;Goldstein, JL
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
56.9
作者：
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Mangelsdorf, DJ