Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.
Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.
复制标题
表达腱生蛋白-C的触觉圆顶角质形成细胞表现出所有表皮谱系的特征。
DOI：
10.1126/sciadv.adi5791
复制
发表时间：
2024-01-19
期刊：
影响因子：
13.6
通讯作者：
Ezhkova, Elena
中科院分区：
文献类型：
--
作者：
Nguyen, Minh Binh;Flora, Pooja;Branch, Meagan C.;Weber, Madison;Zheng, Xiang Yu;Sivan, Unnikrishnan;Joost, Simon;Annusver, Karl;Zheng, Deyou;Kasper, Maria;Ezhkova, Elena
触摸圆顶（TD）角质形成细胞是与光触摸感应默克尔细胞（MC）密切相关的特化表皮细胞。TD角质形成细胞作为MC的小生境发挥作用，并且可以在刺激后诱导从头毛囊;然而，TD角质形成细胞如何在稳态期间维持尚不清楚。scRNA-seq鉴定了特异性TD角质形成细胞标志物，生腱蛋白-C（TNC）。表达Tnc的TD角质形成细胞的谱系追踪显示，这些细胞保持自身作为一个自主的表皮隔室，并在损伤后产生MC。分子表征揭示，虽然TD角质形成细胞的转录和染色质景观与毛囊间表皮角质形成细胞的转录和染色质景观非常相似，但它也与毛囊角质形成细胞共享某些分子特征。我们的研究强调了成人皮肤中TD角质形成细胞具有不同表皮谱系的角质形成细胞的分子特征。成人皮肤中的TD角质形成细胞具有不同表皮谱系的分子特征。
The touch dome (TD) keratinocytes are specialized epidermal cells that intimately associate with the light touch sensing Merkel cells (MCs). The TD keratinocytes function as a niche for the MCs and can induce de novo hair follicles upon stimulation; however, how the TD keratinocytes are maintained during homeostasis remains unclear. scRNA-seq identified a specific TD keratinocyte marker, Tenascin-C (TNC). Lineage tracing of Tnc-expressing TD keratinocytes revealed that these cells maintain themselves as an autonomous epidermal compartment and give rise to MCs upon injury. Molecular characterization uncovered that, while the transcriptional and chromatin landscape of the TD keratinocytes is remarkably similar to that of the interfollicular epidermal keratinocytes, it also shares certain molecular signatures with the hair follicle keratinocytes. Our study highlights that the TD keratinocytes in the adult skin have molecular characteristics of keratinocytes of diverse epidermal lineages. TD keratinocytes in the adult skin have molecular characteristics of diverse epidermal lineages.
登录
查看更多内容
影响因子：
64.5
作者：
Brose, K;Bland, KS;Kidd, T
通讯作者：
Kidd, T
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
8.8
作者：
Boles, Nathan C.;Hirsch, Sarah E.;Fasano, Christopher A.
通讯作者：
Fasano, Christopher A.
影响因子：
7.2
作者：
Chiquet-Ehrismann, Ruth;Tucker, Richard P.
通讯作者：
Tucker, Richard P.