Relationship between lung function and metabolic syndrome.
Relationship between lung function and metabolic syndrome.
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DOI：
10.1371/journal.pone.0108989
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Peng TC
中科院分区：
文献类型：
--
作者：
Chen WL;Wang CC;Wu LW;Kao TW;Chan JY;Chen YJ;Yang YH;Chang YW;Peng TC
尽管肺功能受损与心血管事件和2型糖尿病之间的联系已被认识到，但肺功能受损与代谢综合征之间的关联在美国尚未得到全面评估（U.S.）人口本研究的目的是在全国范围内具有代表性的男性和女性样本中探讨肺功能受损与代谢综合征之间的关系。这项基于人群的横断面研究包括8602名年龄在20-65岁之间的参与者，他们参加了第三次全国健康和营养检查调查（NHANES III）。我们研究了代谢综合征的不同特征与肺功能之间的关系，包括用力肺活量（FVC）和第一秒用力呼气量（FEV 1）。在调整了年龄、体重指数、炎症因子、医疗状况和吸烟状况等潜在混杂因素后，代谢综合征组分较多的参与者FVC和FEV 1的预测值较低（两者趋势p <0.001）。肺功能受损也与代谢综合征的各个组成部分相关，如腹部肥胖、高血压、高甘油三酯和低高密度脂蛋白（HDL）胆固醇（所有参数p<0.05）。这些来自美国成年人全国代表性样本的结果表明，代谢综合征的更多特征与FVC和FEV 1较差密切相关。在临床实践中，需要开发和研究更全面的管理策略来解决代谢综合征和肺功能受损的问题。
Although the link between impaired lung function and cardiovascular events and type 2 diabetes mellitus has been recognized, the association between impaired lung function and metabolic syndrome has not been comprehensively assessed in the United States (U.S.) population. The aim of our study was to explore the association between impaired lung function and metabolic syndrome in a nationally representative sample of men and women. This cross-sectional population-based study included 8602 participants aged 20–65 years in the Third National Health and Nutrition Examination Survey (NHANES III). We examined the relationship between the different features of metabolic syndrome and lung function, including forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). After adjusting for potential confounders such as age, body mass index, inflammatory factors, medical condition, and smoking status, participants with more components of metabolic syndrome had lower predicted values of FVC and FEV1 (p for trend <0.001 for both). Impaired pulmonary function was also associated with individual components of metabolic syndrome, such as abdominal obesity, high blood pressure, high triglycerides, and low high density lipoprotein (HDL) cholesterol (p<0.05 for all parameters). These results from a nationally representative sample of US adults suggest that a greater number of features of metabolic syndrome is strongly associated with poorer FVC and FEV1. In clinical practice, more comprehensive management strategies to address subjects with metabolic syndrome and impaired lung function need to be developed and investigated.
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