Long-term effects of severe acute malnutrition on lung function in Malawian children: a cohort study.
Long-term effects of severe acute malnutrition on lung function in Malawian children: a cohort study.
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DOI：
10.1183/13993003.01301-2016
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Kirkby J
中科院分区：
文献类型：
--
作者：
Lelijveld N;Kerac M;Seal A;Chimwezi E;Wells JC;Heyderman RS;Nyirenda MJ;Stocks J;Kirkby J
早期营养损害可能会增加成人肺部疾病的风险。我们的目的是量化严重急性营养不良 (SAM) 对治疗后 7 年肺量测定结果的影响，并探索肺功能受损的预测因素。对接受 SAM 治疗的 237 名马拉维儿童（中位年龄：9.3岁）进行了肺活量测定和脉搏血氧测定，并与兄弟姐妹和年龄/性别匹配的社区对照进行比较。肺活量测定结果以基于全球肺功能倡议非裔美国人参考数据的 z 分数表示。所有组的 1 s 用力呼气量 (FEV1) 和用力肺活量 (FVC) 均较低（平均 FEV1 z 得分：病例为 -0.47，兄弟姐妹为 -0.48，社区对照为 -0.34；平均 FVC z 得分：分别为 -0.32、-0.38 和 -0.15）。 SAM 幸存者和对照组之间的肺活量或血氧测定结果没有差异。 SAM 幸存者的腿长较短，但组间坐高相似。 HIV 阳性或女性与较差的 FEV1 相关，z 值分别为 0.55 和 0.31。与局部对照相比，儿童早期的 SAM 与随后的肺功能下降无关。保持坐高和妥协的腿长表明“节俭”或“肺保护”生长。女性和艾滋病毒阳性状况被确定为潜在的高危人群。尽管发育迟缓，急性营养不良的幸存者的肺功能并不比对照组差 http://ow.ly/2nvH308LroU
Early nutritional insults may increase risk of adult lung disease. We aimed to quantify the impact of severe acute malnutrition (SAM) on spirometric outcomes 7 years post-treatment and explore predictors of impaired lung function. Spirometry and pulse oximetry were assessed in 237 Malawian children (median age: 9.3 years) who had been treated for SAM and compared with sibling and age/sex-matched community controls. Spirometry results were expressed as z-scores based on Global Lung Function Initiative reference data for the African–American population. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were low in all groups (mean FEV1 z-score: −0.47 for cases, −0.48 for siblings, −0.34 for community controls; mean FVC z-score: −0.32, −0.38, and −0.15 respectively). There were no differences in spirometric or oximetry outcomes between SAM survivors and controls. Leg length was shorter in SAM survivors but inter-group sitting heights were similar. HIV positive status or female sex was associated with poorer FEV1, by 0.55 and 0.31 z-scores, respectively. SAM in early childhood was not associated with subsequent reduced lung function compared to local controls. Preservation of sitting height and compromised leg length suggest “thrifty” or “lung-sparing” growth. Female sex and HIV positive status were identified as potentially high-risk groups. Despite stunting, survivors of acute malnutrition do not have worse lung function than controls http://ow.ly/2nvH308LroU
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DOI：
10.1513/pats.201009-059wr
发表时间：
2011-06-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Crothers, Kristina;Thompson, Bruce W;Huang, Laurence
通讯作者：
Huang, Laurence
DOI：
10.1164/rccm.200908-1190oc
发表时间：
2010-05-15
影响因子：
24.7
作者：
Balinotti, Juan E.;Chakr, Valentina C.;Tepper, Robert S.
通讯作者：
Tepper, Robert S.
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
24.3
作者：
Miller, MR;Hankinson, J;Wanger, J
通讯作者：
Wanger, J
影响因子：
2
作者：
Glew, RH;Brock, HS;VanderJagt, DJ
通讯作者：
VanderJagt, DJ