Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer.
Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer.
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DOI：
10.1016/j.bbi.2012.05.009
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发表时间：
2013-03
影响因子：
15.1
通讯作者：
Antoni, Michael H.
中科院分区：
文献类型：
--
作者：
Antoni, Michael H.
癌症的诊断和后续治疗需要心理适应。行为研究表明，认知，行为和社会因素在积极治疗和整个癌症生存期间促进适应的重要性，这构成了对癌症患者使用许多心理社会干预的基本原理。这种癌症经历也可能影响生理适应系统（例如，神经内分泌）与心理适应变化（负面影响）平行。适应的变化可能会改变与癌症进展和癌症患者生活质量相关的肿瘤生长促进过程（血管生成、迁移和侵袭以及炎症增加）和肿瘤防御过程（细胞免疫力降低）。一些证据表明，心理社会干预可以改善癌症患者的心理和生理适应指标。然而，关于这些干预措施是否可以影响肿瘤活性和肿瘤生长促进过程，以及这些过程的变化是否可以解释迄今为止记录的心理社会干预对复发和生存的影响，人们知之甚少。证明心理社会干预可以调节分子活动（例如，细胞信号传导的转录指示物），其一方面控制肿瘤促进和肿瘤防御过程，另一方面控制临床疾病过程，是生物行为肿瘤学研究的关键挑战。这篇简短的综述将总结当前对癌症经历压力影响的心理和生理适应过程的认识，以及心理社会干预对心理适应，癌症疾病进展和压力相关生物行为过程变化的影响，这些变化可能介导干预对临床癌症结局的影响。最近在乳腺癌中的干预工作将用于阐明感兴趣的分子探针的新兴趋势，希望突出未来的路径，可以推动生物行为肿瘤学干预研究领域的发展。
A diagnosis of cancer and subsequent treatments place demands on psychological adaptation. Behavioral research suggests the importance of cognitive, behavioral, and social factors in facilitating adaptation during active treatment and throughout cancer survivorship, which forms the rationale for the use of many psychosocial interventions in cancer patients. This cancer experience may also affect physiological adaptation systems (e.g., neuroendocrine) in parallel with psychological adaptation changes (negative affect). Changes in adaptation may alter tumor growth-promoting processes (increased angiogenesis, migration and invasion, and inflammation) and tumor defense processes (decreased cellular immunity) relevant for cancer progression and the quality of life of cancer patients. Some evidence suggests that psychosocial intervention can improve psychological and physiological adaptation indicators in cancer patients. However, less is known about whether these interventions can influence tumor activity and tumor growth-promoting processes and whether changes in these processes could explain the psychosocial intervention effects on recurrence and survival documented to date. Documenting that psychosocial interventions can modulate molecular activities (e.g., transcriptional indicators of cell signaling) that govern tumor promoting and tumor defense processes on the one hand, and clinical disease course on the other is a key challenge for biobehavioral oncology research. This mini-review will summarize current knowledge on psychological and physiological adaptation processes affected throughout the stress of the cancer experience, and the effects of psychosocial interventions on psychological adaptation, cancer disease progression, and changes in stress-related biobehavioral processes that may mediate intervention effects on clinical cancer outcomes. Very recent intervention work in breast cancer will be used to illuminate emerging trends in molecular probes of interest in the hope of highlighting future paths that could move the field of biobehavioral oncology intervention research forward.
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影响因子：
10.6
作者：
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作者：
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