Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.
Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.
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DOI：
10.1016/j.biopsych.2011.10.007
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发表时间：
2012-02-15
影响因子：
10.6
通讯作者：
Cole, Steven W.
中科院分区：
文献类型：
--
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
关键词：
慢性威胁和焦虑与循环白细胞中的促炎转录谱相关，但这种关系的因果方向尚未确定。本研究测试了针对负面情绪和认知的认知行为压力管理（CBSM）干预是否可能抵消面临重大医疗威胁的人群中与焦虑相关的转录改变。
199名正在接受0 - III期乳腺癌初级治疗的女性被随机分配到一个为期10周的CBSM方案组或一个积极对照组。79人在基线、6个月和12个月的随访中提供了外周血白细胞样本用于全基因组转录谱分析和生物信息学分析。
基线负面情绪与201种白细胞转录本超过50%的差异表达相关，包括促炎和转移相关基因的表达上调。在随访中，CBSM使91个基因的白细胞表达改变超过50%（组×时间交互作用），包括促炎和转移相关基因的下调以及I型干扰素反应基因的上调。基于启动子的生物信息学分析表明，NF - κB/Rel和GATA家族转录因子活性降低，干扰素反应因子和糖皮质激素受体（GR）活性增加，这些可能是CBSM诱导的转录改变的潜在介质。
在早期乳腺癌患者中，为期10周的CBSM干预可以逆转循环白细胞中与焦虑相关的促炎基因表达上调。这些发现阐明了行为干预能够影响身体健康并改变外周炎症过程的分子信号通路，而外周炎症过程可能反过来影响大脑的情感和认知过程。
Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a Cognitive-Behavioral Stress Management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat. 199 women undergoing primary treatment of Stage 0–III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. 79 provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-, and 12-month follow-ups. Baseline negative affect was associated with > 50% differential expression of 201 leukocyte transcripts, including up-regulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by > 50% at follow-up (Group × Time interaction), including down-regulation of pro-inflammatory and metastasis-related genes and up-regulation of Type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-κB/Rel and GATA family transcription factors and increased activity of Interferon Response Factors and the Glucocorticoid Receptor (GR) as potential mediators of CBSM-induced transcriptional alterations. In early stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related up-regulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.
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影响因子：
11
作者：
Chen, E.;Miller, G. E.;Kobor, M. S.;Cole, S. W.
通讯作者：
Cole, S. W.
影响因子：
3.3
作者：
Antoni, MH;Carrico, AW;Schneiderman, N
通讯作者：
Schneiderman, N
影响因子：
5.8
作者：
Cole, SW;Yan, W;Zack, JA
通讯作者：
Zack, JA
影响因子：
11.5
作者：
Andersen, Barbara L.;Thornton, Lisa M.;Carson, William E., III
通讯作者：
Carson, William E., III
DOI：
10.1073/pnas.0911515107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Cole, Steven W.;Arevalo, Jesusa M. G.;Seeman, Teresa E.
通讯作者：
Seeman, Teresa E.