Anthropometric, demographic, and cardiovascular predictors of left ventricular mass in young children.
Anthropometric, demographic, and cardiovascular predictors of left ventricular mass in young children.
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幼儿左心室质量的人体测量、人口统计和心血管预测因素。
DOI：
10.1016/0002-9149(96)00286-x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Davis,H
中科院分区：
文献类型：
--
作者：
Papavassiliou,DP;Treiber,FA;Strong,WB;Malpass,MD;Davis,H
左心室（LV）质量是心血管疾病发病率和死亡率的一个强有力的独立预测因子。很少有纵向研究对儿童左心室质量的预测因素进行了研究。这项研究评估了68名7.9 ± 0.7岁的白人和非裔美国儿童样本在初次检查3.6年后，人体测量学、人口统计学和心血管参数（休息时和暴露于实验室压力源后）作为左心室质量预测因素的贡献。在初始检查时，所有受试者在休息时和3种应激源（姿势变化、前额冷刺激和跑步机运动）期间进行标准人体测量和血流动力学评估。在3 - 4年后的随访检查中，进行超声心动图评价以估计LV质量和相关LV几何形状。左心室质量和左心室内径在左心室内按线性增长调整（左心室质量/高度分别为2.7和左心室内径/高度分别为0.80）。采用单变量比较有显著性意义的参数进行分层逐步多元回归分析（p <0.05）。初始体重（R2= 0.38）、身高（R2= 0.42）和对站立和踏车运动的心输出量反应性（最终模型R2= 0.55）是左心室质量的显著预测因子，而左心室质量/身高2.7是由初始肥胖（R2= 0.07）和对姿势变化的心输出量和收缩压反应性（最终模型R2= 0.25）预测的。随访时的相对室壁厚度与种族（非裔美国人大于白人，R2= 0.15）、肥胖（R2= 0.20）和收缩压对姿势变化的反应性（最终模型R2= 0.28）有显著相关性。这些研究结果表明，在儿童时期控制体重作为一级预防晚发心血管疾病的潜在益处。(Am J Cardiol 1996;78：323-326）
Left ventricular (LV) mass is a strong independent predictor of cardiovascular morbidity and mortality. Few longitudinal studies have examined predictors of LV mass in children. This study assessed the contributions of anthropometric, demographic, and cardiovascular parameters (at rest and after exposure to laboratory stressors) as predictors of LV mass 3.6 years after the initial examination in a sample of 68 Caucasian and African-American children 7.9 ± 0.7 years old. At the initial examination, all subjects had standard anthropometrics measured and hemodynamics assessed at rest and during 3 stressors: postural change, forehead cold stimulation, and treadmill exercise. On the follow-up examination 3 to 4 years later, echocardiographic evaluations were conducted to estimate LV mass and related LV geometry. LV mass and LV internal diameter in diastole were adjusted for linear growth (LV mass/height2.7and LV internal dimension during diastole/height0.80, respectively). Hierarchical stepwise multiple regression analyses were conducted using parameters significant in univariate comparisons (p <0.05). Initial weight (R2= 0.38), height (R2= 0.42), and cardiac output reactivity to standing and treadmill exercise (final model R2= 0.55) were significant predictors of LV mass, whereas LV mass/height2.7was predicted by initial adiposity (R2= 0.07) and cardiac output and systolic pressure reactivity to postural change (final model R2= 0.25). Follow-up relative wall thickness was significantly predicted by ethnicity (African-Americans greater than Caucasians, R2= 0.15), adiposity (R2= 0.20), and systolic pressure reactivity to postural change (final model R2= 0.28). These findings suggest the potential benefit of weight control in childhood as a primary prevention for later onset of cardiovascular disease. (Am J Cardiol 1996;78:323–326)
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