Sofnolime with different water content causes different effects in two sevoflurane inhalational induction techniques with respect to the output of compound-A.
Sofnolime with different water content causes different effects in two sevoflurane inhalational induction techniques with respect to the output of compound-A.
复制标题
不同含水量的索诺利姆在两种七氟醚吸入诱导技术中对化合物-A的产量产生不同的影响。
DOI：
10.7150/ijms.4436
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发表时间：
2012
影响因子：
3.6
通讯作者：
Li EY
中科院分区：
文献类型：
--
作者：
Liu SJ;Li Y;Sun B;Wang CS;Gong YL;Zhou YM;Li EY
目的：在七氟醚吸入二氧化碳时，影响化合物A(一种具有肾毒性的化学物质)产生的因素尚不清楚。本研究利用模拟肺模型研究了不同新鲜气体流量诱导、肺活量诱导(VCI)和潮气量呼吸诱导(TBI)对新鲜软肺片和脱水软肺片所产生的化合物-A的影响。方法：实验随机分为4组：VCIf组，肺活量新鲜气体注入加新鲜软膏组，TbIf组，潮气量呼吸新鲜气体注入加新鲜软膏组，VCId组，肺活量新鲜气体注入加脱水软膏组，第4组，TBID组，潮气量呼吸新鲜气体注入加脱水软膏组。吸入的七氟醚浓度维持在8%，用气相光谱分析技术测定化合物A的浓度，并在整个实验过程中每隔1分钟监测一次软油醚的温度。结果：肺活量组的平均浓度和最大浓度显著高于潮气量呼吸组(P<；0.01)。维持麻醉开始时，VCIf组血浆化合物A浓度为36.28±6.13ppm，显著高于TBIf组的27.32±4.21ppm(P<0.01)。然而，在脱水的Sofnolime组中，这些值下降到大约2ppm。脱水软化组软化液温度迅速升高，而新鲜软化剂组软化液温度上升较慢。结论：与潮气量呼吸诱导相比，肺活量诱导可增加循环系统中化合物A的产生。然而，对于脱水索尼姆，两种吸入诱导技术对化合物-A产量的影响没有显著差异。
Objective: During sevoflurane anesthesia with Sofnolime for CO2 absorption, the factors affecting the production of compound A (a chemical is nepherotoxic) are still not clear. This study is designed to investigate the effects of different fresh gas flow during induction, the vital capacity induction (VCI) vs. the tidal volume breath induction (TBI) on the compound-A production with a fresh Sofnolime or a dehydrated Sofnolime using a simulated lung model. Method: The experiments were randomly divided into four groups: group one, VCIf, vital capacity fresh gas inflow with fresh Sofnolime; group two, TBIf, tidal volume breath fresh gas inflow with fresh Sofnolime; group three, VCId, vital capacity fresh gas inflow with dehydrated Sofnolime, and group four, TBId, tidal volume breath fresh gas inflow with dehydrated Sofnolime. The inspired sevoflurane was maintained at 8%, the concentrations of compound-A were assayed using Gas-spectrum technique, and Sofnolime temperatures were monitored at 1-min intervals throughout the experiment. Results: The mean and maximum concentrations of compound A were significantly higher in the vital capacity group than the tidal volume breath group (P<0.01). At the beginning of anesthesia maintenance, the compound-A concentration in group VCIf was 36.28±6.13 ppm, which was significantly higher than the 27.32±4.21 ppm observed in group TBIf (P<0.01). However, these values decreased to approximately 2 ppm in the dehydrated Sofnolime groups. Sofnolime temperatures increased rapidly in the dehydrated Sofnolime groups but slowly in the fresh Sofnolime groups. Conclusion: With fresh Sofnolime, vital capacity induction increased compound-A production in the circuit system compared with tidal volume breath induction. However, with dehydrated Sofnolime, the effects of the two inhalation induction techniques on compound-A output were not significantly different.
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肺活量诱导和潮式呼吸诱导技术用于麻醉诱导和化合物 A 产生的比较
影响因子：
6.1
作者：
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通讯作者：
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