High programmed death ligand 1 expression in carcinomatous components predicts a poor prognosis in pulmonary pleomorphic carcinoma
High programmed death ligand 1 expression in carcinomatous components predicts a poor prognosis in pulmonary pleomorphic carcinoma
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癌成分中程序性死亡配体 1 的高表达预示着肺多形性癌的不良预后
DOI：
10.1007/s00595-021-02439-7
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发表时间：
2022
期刊：
影响因子：
2.5
通讯作者：
Date Hiroshi
中科院分区：
文献类型：
--
作者：
Noguchi Misa;Menju Toshi;Nakajima Naoki;Yoshizawa Akihiko;Ohsumi Akihiro;Nakajima Daisuke;Hamaji Masatsugu;Haga Hironori;Date Hiroshi
目的分析46例肺多形性癌的临床病理特征和程序性死亡配体1（programmed death ligand 1，PD-L1）的表达，探讨肺多形性癌的临床行为和影响生存的因素。根据组织成分将肿瘤分为癌性或肉瘤性。在苏木精和伊红染色切片上评价病理学特征。PD-L1在癌和肉瘤组件膜染色的肿瘤细胞的百分比determined.ResultsWe审查了46例患者（41名男性，5名女性，中位年龄70.5岁，范围36-83岁）的数据。大多数肺多形性癌患者表达PD-L1（80.4%），且肿瘤细胞中PD-L1表达的比例在肉瘤成分中显著高于癌成分。在单变量分析中，高p分期（III）、病理学发现坏死和癌性成分中PD-L1高表达（≥ 50%）是总生存期的不良预后因素。在多变量分析中，PD-L1在癌性成分中的高表达与术后预后不良显著相关。
PurposeThis study reviewed the clinicopathological characteristics and programmed death ligand 1 (PD-L1) expression of 46 patients with pulmonary pleomorphic carcinoma to better understand its clinical behavior and factors affecting the survival.MethodsData of patients with pulmonary pleomorphic carcinomas resected in our institution were retrospectively reviewed. The tumors were classified as carcinomatous or sarcomatous according to the tissue components. Pathological characteristics were evaluated on hematoxylin and eosin-stained sections. The percentages of tumor cells with membrane staining for PD-L1 in carcinomatous and sarcomatous components were determined.ResultsWe reviewed data of 46 patients (41 males, 5 females; median age 70.5 years old, range 36–83 years old). Most patients with pulmonary pleomorphic carcinoma expressed PD-L1 (80.4%), and the proportion of PD-L1 expression in tumor cells was significantly higher in sarcomatous components than in carcinomatous components. In univariable analyses, high p-stage (III), necrosis on pathological findings, and high PD-L1 expression in carcinomatous components (≥ 50%) were poor prognostic factors for the overall survival. In multivariable analyses, high PD-L1 expression in carcinomatous components was significantly associated with a poor prognosis after surgery.ConclusionsHigh PD-L1 expression in carcinomatous components was significantly associated with a poor prognosis after surgery.
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晚期头颈癌的氧合：对主要放化疗反应的预后标志
DOI：
--
发表时间：
2000
期刊：
Otolaryngology Head & Neck Surgery
影响因子：
--
作者：
B. Vanselow;M. Eble;V. Rudat;P. Wollensack;C. Conradt;A. Dietz
通讯作者：
A. Dietz
影响因子：
5.6
作者：
Mochizuki, Takahiro;Ishii, Genichiro;Ochiai, Atsushi
通讯作者：
Ochiai, Atsushi
影响因子：
1.2
作者：
Naito, Maiko;Tamiya, Akihiro;Atagi, Shinji
通讯作者：
Atagi, Shinji
影响因子：
5.3
作者：
Cheng, YL;Lee, YC;Wu, CT
通讯作者：
Wu, CT