All y'all need to know 'bout retroelements in cancer.
All y'all need to know 'bout retroelements in cancer.
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DOI：
10.1016/j.semcancer.2010.06.001
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发表时间：
2010-08
影响因子：
14.5
通讯作者：
Deininger PL
中科院分区：
文献类型：
--
作者：
Belancio VP;Roy-Engel AM;Deininger PL
遗传不稳定性是癌症的主要标志和致病因素之一。人类转座因子（TE）已被报道通过对预防或驱动恶性转化的关键基因的插入突变引起人类疾病，包括几种类型的癌症。除了逆转录转座相关诱变之外，已经发现TE通过非等位基因同源重组贡献甚至更多的基因组重排。TE还具有产生广泛突变的潜力，这些突变的来源难以直接追溯到移动的元件，包括可能引发诱变基因组重排的双链断裂。TE启动子的全基因组低甲基化和几乎所有人类癌症中显著升高的TE表达通常伴随着关键DNA传感和修复途径的丧失，这表明移动的元件对基因组稳定性的负面影响应该随着人类肿瘤的演变而增加。在人类癌症中，逆转录因子表达升高的生物学后果，例如其扩增速率，仍然不清楚，特别是这种增加如何转化为疾病相关突变。本文综述了控制人类TE相关突变的细胞机制，并总结了目前对TE对人类恶性肿瘤遗传不稳定性的贡献的认识。
Genetic instability is one of the principal hallmarks and causative factors in cancer. Human transposable elements (TE) have been reported to cause human diseases, including several types of cancer through insertional mutagenesis of genes critical for preventing or driving malignant transformation. In addition to retrotransposition-associated mutagenesis, TEs have been found to contribute even more genomic rearrangements through non-allelic homologous recombination. TEs also have the potential to generate a wide range of mutations derivation of which is difficult to directly trace to mobile elements, including double-strand breaks that may trigger mutagenic genomic rearrangements. Genome-wide hypomethylation of TE promoters and significantly elevated TE expression in almost all human cancers often accompanied by the loss of critical DNA sensing and repair pathways suggests that the negative impact of mobile elements on genome stability should increase as human tumors evolve. The biological consequences of elevated retroelement expression, such as the rate of their amplification, in human cancers remain obscure, particularly, how this increase translates into disease-relevant mutations. This review is focused on the cellular mechanisms that control human TE-associated mutagenesis in cancer and summarizes the current understanding of TE contribution to genetic instability in human malignancies.
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LINE-1 RNA剪接和对哺乳动物基因表达的影响。
影响因子：
14.9
作者：
Belancio, VP;Hedges, DJ;Deininger, P
通讯作者：
Deininger, P
影响因子：
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作者：
通讯作者：
--
DOI：
10.1073/pnas.0831042100
发表时间：
2003-04-29
影响因子：
11.1
作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
10.5
作者：
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