Analysis of EphB receptors and their ligands in the developing retinocollicular system of the wallaby reveals dynamic patterns of expression in the retina
Analysis of EphB receptors and their ligands in the developing retinocollicular system of the wallaby reveals dynamic patterns of expression in the retina
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对小袋鼠发育中的视网膜小球系统中的 EphB 受体及其配体的分析揭示了视网膜中表达的动态模式
DOI：
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发表时间：
2003
影响因子：
3.4
通讯作者：
L. Marotte
中科院分区：
文献类型：
--
作者：
M. Vidovic;L. Marotte
The expression of EphB1 and B2 receptors and ephrins‐B1, ‐B2 and ‐B3 in the retina and superior colliculus of the wallaby (Macropus eugenii) was examined during the development of the retinocollicular projection, using reverse transcription–polymerase chain reaction and immunohistochemistry. There was an early transient differential expression of EphB2 that was higher in ventral retina and restricted to the outer neuroblast layer, whereas a high ventral to low dorsal gradient of ephrin‐B2 expression occurred there throughout the study period. However, there was no dorsoventral gradient of receptors or ligands in retinal ganglion cells or a mediolateral gradient of ephrins in the colliculus. These findings suggest a limited role for these molecules in topographic mapping across the mediolateral colliculus in the wallaby. Early in retinal development there is a complementary pattern of expression of ephrin‐B1 and ‐B2 in the outer neuroblast layer that overlaps with expression of EphB2. Ganglion and amacrine cells also express EphB2. As development proceeds subpopulations of putative horizontal and bipolar cells, also expressing EphB2, come to reside in the inner nuclear layer and ephrin‐B1 is expressed throughout the outer nuclear layer. At the same time cells expressing ephrin‐B2, and subpopulations of horizontal and bipolar cells come to reside in the inner nuclear layer and there is a corresponding decrease in ephrin‐B2 expression in the outer nuclear layer. This pattern of coexpression of receptors and ligands suggests a role for them in cell migration and maintenance of laminar boundaries.
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鸡胚激酶 5 的鉴定，一种 Eph 家族发育调节受体型酪氨酸激酶。
DOI：
10.1091/mbc.2.7.523
发表时间：
1991
期刊：
Cell regulation
影响因子：
--
作者：
Pasquale,EB
通讯作者：
Pasquale,EB
NET(EPHT2)（一种优先在脑中表达的人 EPH 相关受体蛋白酪氨酸激酶基因）的 cDNA 克隆、分子表征和染色体定位。
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10.1006/geno.1995.9985
发表时间：
1995
期刊：
Genomics.
影响因子：
--
作者：
Tang,XX;Biegel,JA;Nycum,LM;Yoshioka,A;Brodeur,GM;Pleasure,DE;Ikegaki,N
通讯作者：
Ikegaki,N
EphB 受体在视网膜轴突从背侧而非腹侧视网膜寻路至视盘中的激酶独立功能。
DOI：
10.1242/dev.127.6.1231
发表时间：
2000
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Birgbauer,E;Cowan,CA;Sretavan,DW;Henkemeyer,M
通讯作者：
Henkemeyer,M
五种新型禽类 Eph 相关酪氨酸激酶存在差异表达。
影响因子：
8
作者：
Sajjadi,FG;Pasquale,EB
通讯作者：
Pasquale,EB