In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM.
In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM.
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DOI：
10.1016/j.nicl.2013.03.017
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发表时间：
2013
影响因子：
4.2
通讯作者：
Sato, Noriko
中科院分区：
文献类型：
--
作者：
Shigemoto, Yoko;Matsuda, Hiroshi;Kamiya, Kouhei;Maikusa, Norihide;Nakata, Yasuhiro;Ito, Kimiteru;Ota, Miho;Matsunaga, Naofumi;Sato, Noriko
关键词：
在以帕金森病为主的多系统萎缩（MSA-P）中，一些基于体素的形态测量（VBM）研究揭示了灰质损失；然而，白质体积变化的报道却很少。我们通过 VBM 研究了白质和灰质的体积变化。对 20 名 MSA-P 患者和 30 名年龄匹配的健康对照者进行了回顾性 MRI 研究。我们应用 VBM 结合统计参数映射 (SPM8) 加上通过指数李代数 (DARTEL) 进行的微分同胚解剖配准来探索所有 MSA-P 患者的灰质和白质区域萎缩情况，与对照组相比，其中 14 名左侧占主导地位的患者和 6 名右侧占主导地位的患者。在所有 MSA-P 患者中，VBM 显示双侧壳核、小脑和背侧中脑灰质体积显着减少。白质缺失位于双侧苍白球、外囊延伸至中脑、右侧皮层下经内囊至中央前区、脑桥、双侧小脑中脚和左侧小脑。在左侧占优势的 MSA-P 患者中，主要在右侧检测到灰质和白质体积损失，在右侧占优势的 MSA-P 患者中反之亦然。未检测到与疾病持续时间和严重程度的相关性。使用 SPM8 加 DARTEL 的 VBM 检测到受 MSA-P 影响的区域的灰质和白质均出现显着的体积损失。通过 MSA-P 中的 VBM 研究灰质和白质的体积变化。检测到每个结构的苍白球体积损失。灰质和白质体积损失与偏侧性的临床发现非常吻合。
In multiple system atrophy with predominant parkinsonism (MSA-P), several voxel-based morphometry (VBM) studies have revealed gray matter loss; however, the white matter volume changes have been rarely reported. We investigated the volume changes of white matter as well as gray matter by VBM. A retrospective MRI study was performed in 20 patients with MSA-P and 30 age-matched healthy controls. We applied VBM with statistical parametric mapping (SPM8) plus diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) to explore the regional atrophy of gray and white matter in all of the MSA-P patients, 14 patients with left-side dominant and 6 patients with right-side dominant onset as compared to controls. In all of the MSA-P patients, VBM revealed a significant volume reduction of gray matter in the bilateral putamina, cerebellums and dorsal midbrain. White matter loss was located in bilateral globus pallidi, external capsules extending to the midbrain, right subcortical to precentral area through internal capsule, the pons, bilateral middle cerebellar peduncles and left cerebellum. In left-side dominant MSA-P patients, the gray and white matter volume loss was detected predominantly on the right side and vice versa in right-side dominant MSA-P patients. A correlation with disease duration and severity was not detected. VBM using SPM8 plus DARTEL detected significant volume loss not only in the gray but also in the white matter of the area affected by MSA-P. Volume changes of gray and white matter were investigated by VBM in MSA-P. Volume loss of globus pallidus with each structure was detected. Gray and white matter volume loss agreed well with clinical findings in laterality.
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影响因子：
5.1
作者：
Chang, C. C.;Chang, Y. Y.;Liu, W. L.
通讯作者：
Liu, W. L.
影响因子：
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Revesz, T
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Wenning, GK
影响因子：
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作者：
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