Reduced asymmetry of the hand knob area and decreased sensorimotor u-fiber connectivity in middle-aged adults with autism.
Reduced asymmetry of the hand knob area and decreased sensorimotor u-fiber connectivity in middle-aged adults with autism.
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DOI：
10.1016/j.cortex.2022.04.004
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发表时间：
2022-08
期刊：
影响因子：
3.6
通讯作者：
Carper, Ruth A.
中科院分区：
文献类型：
--
作者：
Hau, Janice;Baker, Ashley;Chaaban, Chantal;Kohli, Jiwandeep S.;Keehn, R. Joanne Jao;Linke, Annika C.;Mash, Lisa E.;Wilkinson, Molly;Kinnear, Mikaela K.;Muller, Ralph-Axel;Carper, Ruth A.
患有自闭症谱系障碍（ASD）的个体经常表现出运动技能的损伤（例如，肢体协调、书写和平衡），这些问题在整个生命周期中都可以观察到，但基本上没有得到治疗。因此，许多患有ASD的成年人可能会在衰老过程中经历不良的运动结果，此时自然发生身体衰退。感觉运动皮层的“手旋钮”是一个对手指和手的运动控制至关重要的区域。然而，这个区域在ASD研究中很少受到关注，特别是在中年后的成年人中。在49名右利手成人（25名ASD，24名典型比较[TC]参与者，年龄41-70岁）中半手动描绘中央前回（PrChand）和中央后回（PoChand）的手旋钮区域。使用多模态（T1加权，弥散加权，静息状态功能）MRI，我们检查了这些区域的形态，同侧连接和偏侧性。我们还探讨了手柄测量与运动技能和自闭症症状之间的相关性，以及结构和功能连接测量之间的相关性。贝叶斯分析表明，组效应的中度证据，更大的右PrChand体积和减少的PrChand和PoChand体积在ASD相对于TC组的单侧性。此外，右PoC-PrChand u纤维显示ASD组的平均扩散率增加。在ASD组中，右U纤维体积与相应的功能连接呈正相关，但没有生存多重比较校正。在ASD组中观察到手柄测量和行为的相关性，但在多重比较校正中没有存活。我们的研究结果表明，形态偏侧性和u-纤维连接的感觉运动网络，参与手运动/运动前功能，可能会减少在中年成人ASD，也许使他们更容易在老年运动衰退。改变的形态可能与早期ASD中发现的非典型功能性运动不对称有关，可能反映了随着时间的推移功能不对称的改变。
Individuals with autism spectrum disorder (ASD) frequently present with impairments in motor skills (e.g., limb coordination, handwriting and balance), which are observed across the lifespan but remain largely untreated. Many adults with ASD may thus experience adverse motor outcomes in aging, when physical decline naturally occurs. The ‘hand knob’ of the sensorimotor cortex is an area that is critical for motor control of the fingers and hands. However, this region has received little attention in ASD research, especially in adults after midlife. The hand knob area of the precentral (PrChand) and postcentral (PoChand) gyri was semi-manually delineated in 49 right-handed adults (25 ASD, 24 typical comparison [TC] participants, aged 41–70 years). Using multimodal (T1-weighted, diffusion-weighted, and resting-state functional) MRI, we examined the morphology, ipsilateral connectivity and laterality of these regions. We also explored correlations between hand knob measures with motor skills and autism symptoms, and between structural and functional connectivity measures. Bayesian analyses indicated moderate evidence of group effects with greater right PrChand volume and reduced leftward laterality of PrChand and PoChand volume in the ASD relative to TC group. Furthermore, the right PoC-PrChand u-fibers showed increased mean diffusivity in the ASD group. In the ASD group, right u-fiber volume positively correlated with corresponding functional connectivity but did not survive multiple comparisons correction. Correlations of hand knob measures and behavior were observed in the ASD group but did not survive multiple comparisons correction. Our findings suggest that morphological laterality and u-fiber connectivity of the sensorimotor network, putatively involved in hand motor/premotor function, may be diminished in middle-aged adults with ASD, perhaps rendering them more vulnerable to motor decline in old age. The altered morphology may relate to atypical functional motor asymmetries found in ASD earlier in life, possibly reflecting altered functional asymmetries over time.
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影响因子：
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作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
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DOI：
10.1016/j.nicl.2014.11.004
发表时间：
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DOI：
10.1093/brain/awx270
发表时间：
2017-11-01
期刊：
Brain : a journal of neurology
影响因子：
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作者：
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Catani M