Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder.
Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder.
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DOI：
10.1001/jamapsychiatry.2013.382
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发表时间：
2013-09
期刊：
影响因子：
25.8
通讯作者：
Mueller, Ralph-Axel
中科院分区：
文献类型：
--
作者：
Cardinale, Ryan C.;Shih, Patricia;Fishman, Inna;Ford, Leanne M.;Mueller, Ralph-Axel
自闭症谱系障碍（ASD）是一种以脑为基础的广泛性发育障碍，通过不断增长的共识，与功能网络的异常组织有关。先前的几项自闭症研究表明，语言存在非典型的半球不对称性。使用数据驱动的方法对ASD的半球不对称性进行全面调查，以检查功能网络的不对称性。这项横断面研究涉及圣地亚哥州立大学和加州大学圣地亚哥分校的24名ASD儿童和26名正常发育儿童。10名儿童的数据因过度运动而被排除在外，最终每组20名参与者。从静息态功能磁共振成像数据的独立成分分析确定功能网络的不对称指数。时间串联独立成分分析，分别在每组中进行，显示显着的组间差异的不对称指数为10的17个功能网络。无一例外，这些网络（视觉，听觉，运动，执行，语言和注意力）在ASD组中表现出非典型的非对称性变化。非典型的大脑不对称性可能是ASD患者大脑功能组织的普遍特征，影响感觉运动和更高的认知领域。
Autism spectrum disorder (ASD) is a brain-based pervasive developmental disorder, which—by growing consensus—is associated with abnormal organization of functional networks. Several previous studies of ASD have indicated atypical hemispheric asymmetries for language. To examine the asymmetry of functional networks using a data-driven approach for a comprehensive investigation of hemispheric asymmetry in ASD. This cross-sectional study involved 24 children with ASD and 26 matched typically developing children at San Diego State University and the University of California, San Diego. Data from 10 children had to be excluded for excessive motion, resulting in final samples of 20 participants per group. Asymmetry indices of functional networks identified from independent component analysis of resting-state functional magnetic resonance imaging data. Temporal concatenation independent component analysis, performed separately in each group, showed significant group differences in asymmetry indices for 10 out of 17 functional networks. Without exception, these networks (visual, auditory, motor, executive, language, and attentional) showed atypical rightward asymmetry shifts in the ASD group. Atypical rightward asymmetrymay be a pervasive feature of functional brain organization in ASD, affecting sensorimotor, as well as higher cognitive, domains.
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影响因子：
10.6
作者：
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通讯作者：
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DOI：
10.1098/rstb.2005.1634
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