Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.
Engineering of bioactive nanocomplexes on dental floss for targeted gingival therapy.
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DOI：
10.1002/btm2.10452
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发表时间：
2023-03
影响因子：
7.4
通讯作者：
Mitragotri, Samir
中科院分区：
文献类型：
--
作者：
Nakajima, Mayuka;Nakajima, Nao;Guo, Junling;Mitragotri, Samir
慢性龈下感染引起的牙周炎是一种普遍存在的疾病，会引起全身炎症后果并对生活质量造成负面影响。通过患者的自我护理，旨在消除该区域的口腔病原体，可以治疗并可能预防该疾病。目前用于牙间自我护理的产品，包括牙线和牙间刷，预防这种疾病的能力有限。在这里，我们报告了一种被称为“纳米牙线”的涂层牙线，它使用基于多酚的纳米涂层通过治疗剂使牙线线功能化。多种疗法可以集成到纳米牙线中，包括抗菌小分子和蛋白质。使用纳米牙线将治疗剂输送到具有挑战性的龈下区域，即使在体内口腔液的冲洗作用下也能长期保留。我们的体外和体内研究表明，负载葡萄糖酸氯己定的纳米牙线可以有效治疗牙龈卟啉单胞菌的龈下感染。总的来说，纳米牙线为针对牙周炎的龈下感染的有针对性的自我护理提供了一种有前途且易于使用的工具。
Periodontitis induced by chronic subgingival infection is a ubiquitous disease that causes systemic inflammatory consequences and poses a negative impact on quality of life. The disease is treated and potentially prevented by patient's self‐care aimed at eliminating the oral pathogens from the region. Currently available products for interdental self‐care, including dental floss and interdental brush, have limited ability to prevent the disease. Here, we report a coated dental floss thread, termed “nanofloss,” which uses polyphenol‐based nanocoating to functionalize the floss thread with therapeutic agents. Multiple therapeutics can be integrated into the nanofloss including antibacterial small molecules and proteins. Flossing with nanofloss‐delivered therapeutic agents to the challenging subgingival region with long‐term retention even against the flushing action of the oral fluid in vivo. Our in vitro and in vivo studies demonstrate that chlorhexidine gluconate‐loaded nanofloss effectively treats the subgingival infection by Porphyromonas gingivalis. Collectively, the nanofloss offers a promising and easily usable tool for targeted self‐care of subgingival infection against periodontitis.
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