Hybrids of amphibian chytrid show high virulence in native hosts.
Hybrids of amphibian chytrid show high virulence in native hosts.
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两栖动物糜烂丝虫的杂交种对本地宿主具有很强的毒力。
DOI：
10.1038/s41598-018-27828-w
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发表时间：
2018-06-25
影响因子：
4.6
通讯作者：
Becker CG
中科院分区：
文献类型：
--
作者：
Greenspan SE;Lambertini C;Carvalho T;James TY;Toledo LF;Haddad CFB;Becker CG
寄生虫的杂交可以产生具有高毒力的新基因型。真菌两栖类寄生虫Batrachochytrium dendrobatium（Bd）在巴西的大西洋森林中杂交，这是一个生物多样性热点，其中两栖类的下降与Bd有关，但杂交基因型在本地宿主中的毒力从未被测试过。我们比较了毒力（宿主死亡率和感染负担）的杂交Bd基因型的父母的血统，pupestival的低毒力谱系Bd-巴西和高毒力的全球大流行谱系（Bd-GPL），在一个小组的巴西本地主机。在Brachycephalus ephippium，杂交超过了父母双方的毒力（宿主死亡率），这表明杂交Bd产生的新奇是一个保护问题。在小寄生虫，在杂交处理的主机死亡率是中间的父母之间的治疗，这表明该物种更容易受到侵略性的表型与Bd-GPL。Dendropsophus minutus表现出较低的总体死亡率，但感染负担较高的杂交和Bd-GPL基因型处理的青蛙比Bd-Brazil基因型。我们的实验表明，Bd杂交种有可能增加本地宿主的疾病风险。需要持续监测，以跟踪杂交基因型的潜在传播，并检测这一动态疾病系统中未来的基因组变化。
Hybridization of parasites can generate new genotypes with high virulence. The fungal amphibian parasite Batrachochytrium dendrobatidis (Bd) hybridizes in Brazil’s Atlantic Forest, a biodiversity hotspot where amphibian declines have been linked to Bd, but the virulence of hybrid genotypes in native hosts has never been tested. We compared the virulence (measured as host mortality and infection burden) of hybrid Bd genotypes to the parental lineages, the putatively hypovirulent lineage Bd-Brazil and the hypervirulent Global Pandemic Lineage (Bd-GPL), in a panel of native Brazilian hosts. In Brachycephalus ephippium, the hybrid exceeded the virulence (host mortality) of both parents, suggesting that novelty arising from hybridization of Bd is a conservation concern. In Ischnocnema parva, host mortality in the hybrid treatment was intermediate between the parent treatments, suggesting that this species is more vulnerable to the aggressive phenotypes associated with Bd-GPL. Dendropsophus minutus showed low overall mortality, but infection burdens were higher in frogs treated with hybrid and Bd-GPL genotypes than with Bd-Brazil genotypes. Our experiment suggests that Bd hybrids have the potential to increase disease risk in native hosts. Continued surveillance is needed to track potential spread of hybrid genotypes and detect future genomic shifts in this dynamic disease system.
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影响因子：
2.9
作者：
Becker, C. G.;Greenspan, S. E.;Zamudio, K. R.
通讯作者：
Zamudio, K. R.
影响因子：
56.9
作者：
Becker, Carlos Guilherme;Fonseca, Carlos Roberto;Prado, Paulo Inacio
通讯作者：
Prado, Paulo Inacio
影响因子：
3.6
作者：
Couteaudier, Y;Viaud, M;Riba, G
通讯作者：
Riba, G
影响因子：
4.9
作者：
Bataille, Arnaud;Fong, Jonathan J.;Waldman, Bruce
通讯作者：
Waldman, Bruce
影响因子：
2.4
作者：
Burrowes, PA;Joglar, RL;Green, DE
通讯作者：
Green, DE