Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.
复制标题
DOI：
10.1016/j.cmet.2008.06.005
复制
发表时间：
2008-08
期刊：
影响因子：
29
通讯作者：
Ashrafi, Kaveh
中科院分区：
文献类型：
--
作者：
Greer, Elisabeth R.;Perez, Carissa L.;Van Gilst, Marc R.;Lee, Brian H.;Ashrafi, Kaveh
了解能量平衡的一个主要挑战是破译控制动物对波动的环境条件的行为、生理和代谢反应的神经和分子回路。神经表达的 TGF-β 配体 DAF-7 充当环境条件的衡量指标，以调节秀丽隐杆线虫的能量平衡。我们表明，daf-7 信号通过紧凑的神经回路调节脂肪代谢和进食行为，该神经回路允许整合多个输入，并灵活地对输出进行差异调节。尽管摄食率降低，但 daf-7 突变体认为食物资源耗尽会导致脂肪积累。这种脂肪积累部分是通过神经代谢型谷氨酸信号传导和外周内源性生物合成途径的上调来介导的，这些途径将能量资源引导到脂肪库中。因此，神经对不利环境条件的感知可以促进脂肪积累，而不会同时增加摄食率。
A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-β ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple inputs, and the flexibility for differential regulation of outputs. Perception of depleting food resources in daf-7 mutants causes fat accumulation despite reduced feeding rate. This fat accumulation is mediated, in part, through neural metabotropic glutamate signaling and upregulation of peripheral endogenous biosynthetic pathways that direct energetic resources into fat reservoirs. Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate.
登录
查看更多内容
影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
影响因子：
16.8
作者：
Asturias, FJ;Chadick, JZ;Smith, S
通讯作者：
Smith, S
影响因子：
--
作者：
AVERY, L;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
2.7
作者：
CASSADA, RC;RUSSELL, RL
通讯作者：
RUSSELL, RL
影响因子：
7
作者：
Deplancke, B;Dupuy, D;Walhout, AJM
通讯作者：
Walhout, AJM