Association of uterine fibroids with birthweight and gestational age.
Association of uterine fibroids with birthweight and gestational age.
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DOI：
10.1016/j.annepidem.2020.06.012
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发表时间：
2020-10
影响因子：
5.6
通讯作者：
Velez Edwards DR
中科院分区：
文献类型：
--
作者：
Zhao SK;Wu P;Jones SH;Torstenson ES;Hartmann KE;Velez Edwards DR
确定子宫肌瘤或其特征是否与出生体重和/或胎龄有关，并评估种族或民族的影响。Right from the Start（2000-2012）是一项前瞻性队列研究，招募了来自美国南部的早期怀孕妇女。经阴道超声测量肌瘤特征并确认胎龄。出生日期和出生体重是从生命或医疗记录中获得的。我们使用协方差的多变量分析来评估子宫肌瘤的存在、数量、类型和体积是否与出生体重和/或胎龄相关，并考虑了先验混杂因素。在3926名女性中，416名有一个或多个肌瘤。有子宫肌瘤和无子宫肌瘤妇女的平均婴儿出生体重和胎龄相似。当调整种族或民族时，所有关联都减弱了。总的来说，有和没有肌瘤的妇女所生婴儿的出生体重（- 20克，95%可信区间[CI] - 77, 36）和胎龄（0.4天，95% CI - 0.9, 1.8）相似。有三个或三个以上肌瘤的妇女更有可能生出体重较轻的婴儿（- 201克，95% CI - 345, - 58）。种族或民族实质上混淆了这种联系。临床认为子宫肌瘤损害胎儿生长的观点只有在多发性子宫肌瘤妇女出生体重显著下降的情况下才得到支持。我们的前瞻性妊娠队列表明，有三个或更多肌瘤的妇女比没有肌瘤的妇女更有可能生出体重较轻的婴儿。在胎龄方面未观察到有意义的肌瘤相关差异。
To determine if fibroids or their characteristics are associated with birthweight and/or gestational age, and to assess the impact of race or ethnicity. Right from the Start (2000–2012) is a prospective cohort that enrolled women from the southern US in early pregnancy. Transvaginal ultrasounds were used to measure fibroid characteristics and confirm gestational age. Date of birth and birthweight were obtained from vital or medical records. We assessed whether fibroid presence, number, type, and volume were associated with birthweight and/or gestational age using multivariate analysis of covariance, accounting for a priori confounders. Among 3926 women, 416 had one or more fibroids. Mean infant birthweight and gestational age were similar among women with and without fibroids. When adjusting for race or ethnicity, all associations were attenuated. Overall, women with and without fibroids had infants of similar birthweight (−20 grams, 95% confidence interval [CI] −77, 36) and gestational age (0.4 days, 95% CI −0.9, 1.8). Women with three or more fibroids were more likely to have lighter infants (−201 grams, 95% CI −345, −58). Race or ethnicity substantially confounds the associations. The clinical belief that uterine fibroids impair fetal growth is supported only by a significant decrease in birthweight for women with multiple fibroids. Our prospective pregnancy cohort suggests women with three or more fibroids are more likely to have lighter infants than those without. No meaningful fibroid-related differences were observed in gestational age.
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