Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
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端粒磨损与抗高血压治疗和降压效果的纵向关联
DOI：
10.14336/ad.2019.0721
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发表时间：
2019-07
影响因子：
7.4
通讯作者：
Weili Zhang
中科院分区：
文献类型：
--
作者：
Shuyuan Zhang;Rongxia Li;Yunyun Yang;Shujun Yang;Jian Li;Cunjin Wu;Tao Kong;Tianlong Liu;Jun Cai;Li Fu;Yanan Zhao;Rutai Hui;Weili Zhang
白细胞端粒长度与高血压相关，但端粒长度变化是否能作为高血压的预测工具仍不确定。本研究旨在对1,108名高血压患者进行基于人群的前瞻性研究，以检查白细胞端粒长度的纵向轨迹。在基线时测量白细胞端粒长度，并在中位数2.2（范围1.5-2.4）年随访后再次测量。年龄作为一个独立的预测因素与基线端粒和随访端粒呈负相关。年端粒磨损率计算为（随访端粒-基线端粒）/随访年，参与者分为缩短组和延长组。结果表明，端粒延长与收缩压（SBP）降低显著相关（β=-3.28; P=0.02）和脉压（PP）（β=-2.53，P =0.02），差异分别为-3.3mmHg校正血管危险因素和基线血压后，两组间SBP和SBP均显著降低（95%CI，-6.2至-0.3; P=0.03），SBP和SBP均显著降低（95%CI，-4.9至-0.1; P=0.04）。当按年龄和性别分层时，在女性和≤60岁的患者中观察到了相关性。此外，在使用钙通道阻滞剂（CCB）和血管紧张素受体阻滞剂（ARB）的患者中，端粒延长的患者的SBP和PP水平显著降低。端粒磨损与心血管事件的发生率之间没有相关性。我们的数据表明，白细胞端粒长度增加与SBP和PP降低相关，特别是对于接受CCB和ARB的患者，支持端粒磨损可能为高血压的临床干预提供新的视角。
Leukocytes telomere length has been associated with hypertension, but, whether longitudinal telomeres change could serve as a useful predictive tool in hypertension remains uncertain. This study aimed to examine the longitudinal trajectory of leukocytes telomere length in a population-based prospective study of 1,108 individuals with hypertension. Leukocytes telomere length were measured at baseline and again after a median 2.2 (range 1.5-2.4) years of follow-up. Age as an independent predictor was inversely associated with baseline telomeres and follow-up telomeres. Annual telomere attrition rate was calculated as (follow-up telomeres-baseline telomeres)/follow-up years, and participants were categorized into the shorten and the lengthen groups. Results showed that telomere lengthening was significantly correlated with decreased systolic blood pressure (SBP) (β=-3.28; P=0.02) and pulse pressure (PP) (β=-2.53; P=0.02), and the differences were respectively -3.3 mmHg (95%CI, -6.2 to -0.3; P=0.03) in ∆SBP and -2.4 mmHg (95%CI, -4.9 to -0.1; P=0.04) in ∆PP between two groups after adjustment for vascular risk factors and baseline blood pressures. When stratified by age and gender, the correlations were observed in women and patients ≤60 years. Furthermore, among patients using calcium channel blocker (CCB) and angiotensin receptor blocker (ARB), those with telomeres lengthening showed a significantly lower level of ∆SBP and ∆PP. There was no correlation between telomere attrition and incidence of cardiovascular events. Our data indicated that increased telomere length of leukocytes was associated with decreased SBP and PP, particularly for patients who received CCB and ARB, supporting that telomere attrition may provide new sight in clinical intervention for hypertension.
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DOI：
10.1016/s0145-4145(08)04003-3
发表时间：
2008
期刊：
Yearbook of Cardiology
影响因子：
--
作者：
B. Gersh
通讯作者：
B. Gersh
影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
端粒缩短和心血管损伤的速度：1946年英国出生队列的纵向研究。
影响因子：
39.3
作者：
Masi S;D'Aiuto F;Martin-Ruiz C;Kahn T;Wong A;Ghosh AK;Whincup P;Kuh D;Hughes A;von Zglinicki T;Hardy R;Deanfield JE;NSHD scientific and data collection teams
通讯作者：
NSHD scientific and data collection teams
影响因子：
5.4
作者：
Said MA;Eppinga RN;Lipsic E;Verweij N;van der Harst P
通讯作者：
van der Harst P
影响因子：
3.6
作者：
K. Okuda;A. Bardeguez;J. Gardner;Paulette Rodriguez;V. Ganesh;M. Kimura;J. Skurnick;G. Awad
通讯作者：
K. Okuda;A. Bardeguez;J. Gardner;Paulette Rodriguez;V. Ganesh;M. Kimura;J. Skurnick;G. Awad