A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG.
A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG.
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DOI：
10.1016/j.eplepsyres.2011.05.011
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发表时间：
2011-09
影响因子：
2.2
通讯作者：
Litt, Brian
中科院分区：
文献类型：
--
作者：
Davis, Kathryn A.;Sturges, Beverly K.;Vite, Charles H.;Ruedebusch, Vanessa;Worrell, Gregory;Gardner, Andrew B.;Leyde, Kent;Sheffield, W. Douglas;Litt, Brian
我们目前的结果，连续颅内脑电图（iEEG）监测6只狗自然发生的癫痫，一种疾病类似于人类的条件，在其临床表现，流行病学，电生理和治疗反应。记录是使用一种新型的可植入设备无线连接到外部，便携式实时处理单元。我们证明了这些动物先前未表征的颅内癫痫发作模式在外观上与人类部分发作性癫痫惊人相似。我们建议：（1）犬癫痫作为测试人类抗癫痫器械和癫痫手术新方法的适当模型，以及（2）这项新技术作为评估癫痫发作和在自然、门诊环境中对治疗反应的多功能平台。
We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.
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影响因子：
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