Herpesvirus reactivation during severe COVID-19 and high rate of immune defect.
Herpesvirus reactivation during severe COVID-19 and high rate of immune defect.
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DOI：
10.1016/j.idnow.2021.07.005
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发表时间：
2021-11
影响因子：
3.5
通讯作者：
Darmon M
中科院分区：
文献类型：
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作者：
Saade A;Moratelli G;Azoulay E;Darmon M
我们评估了严重SARS-CoV-2感染中疱疹病毒的再激活。回顾性研究包括因严重COVID-19而连续入住肿瘤-血液学重症监护病房（ICU）的患者。评估EBV、CMV和HSV的复制。竞争风险分析用于评估病毒再激活的累积风险，时间依赖性Cox和Fine and Gray模型用于评估病毒再激活的风险因素。100例患者中，38例免疫功能低下。63例患者出现病毒再激活（12%为HSV， 58%为EBV， 19%为CMV）。有症状的患者接受治疗。10天病毒再激活的总累积发生率为56.1%[55.9-56.4]。调整后，先前存在的血液系统恶性肿瘤（sHR [95%CI] = 0.31[0.11-0.85]）和实体器官移植（sHR [95%CI] = 2.09[1.13-3.87]）仍然与病毒再激活独立相关。病毒再激活（P = 0.34）与死亡率无关。重症COVID-19住院ICU患者疱疹病毒再激活发生率高，但很少需要抗病毒治疗。
We assessed herpesvirus reactivation in severe SARS-CoV-2 infection. Retrospective study including consecutive patients admitted to an onco-hematology intensive care unit (ICU) for severe COVID-19. Replication of EBV, CMV, and HSV was evaluated. Competing risk analyses were used to assess the cumulative risk of viral reactivation, and time-dependent Cox and Fine and Gray models to assess risk factors for viral reactivation. Among 100 patients, 38 were immunocompromised. Sixty-three patients presented viral reactivation (12% for HSV, 58% EBV and 19% CMV). Symptomatic patients received treatment. Overall cumulative incidence of viral reactivation was 56.1% [55.9–56.4] at 10 days. After adjustment, a preexisting hematological malignancy (sHR [95%CI] = 0.31 [0.11–0.85]) and solid organ transplantation (sHR [95% CI] = 2.09 [1.13–3.87]) remained independently associated with viral reactivation. Viral reactivation (P = 0.34) was not associated with mortality. Incidence of herpesvirus reactivation in patients admitted to the ICU for severe COVID-19 was high, but rarely required antiviral treatment.
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DOI：
10.1186/s13054-021-03460-5
发表时间：
2021-01-11
期刊：
Critical care (London, England)
影响因子：
--
作者：
Maes M;Higginson E;Pereira-Dias J;Curran MD;Parmar S;Khokhar F;Cuchet-Lourenço D;Lux J;Sharma-Hajela S;Ravenhill B;Hamed I;Heales L;Mahroof R;Soderholm A;Forrest S;Sridhar S;Brown NM;Baker S;Navapurkar V;Dougan G;Bartholdson Scott J;Conway Morris A
通讯作者：
Conway Morris A
影响因子：
120.7
作者：
Limaye, Ajit P.;Kirby, Katharine A.;Rubenfeld, Gordon D.;Leisenring, Wendy M.;Bulger, Eileen M.;Neff, Margaret J.;Gibran, Nicole S.;Huang, Meei-Li;Hayes, Tracy K. Santo;Corey, Lawrence;Boeckh, Michael
通讯作者：
Boeckh, Michael
影响因子：
8.1
作者：
Hraiech, Sami;Bonnardel, Eline;Papazian, Laurent
通讯作者：
Papazian, Laurent
影响因子：
8.1
作者：
Luyt CE;Sahnoun T;Gautier M;Vidal P;Burrel S;Pineton de Chambrun M;Chommeloux J;Desnos C;Arzoine J;Nieszkowska A;Bréchot N;Schmidt M;Hekimian G;Boutolleau D;Robert J;Combes A;Chastre J
通讯作者：
Chastre J
影响因子：
21.1
作者：
Jin, Ying-Hui;Cai, Lin;Wang, Xing-Huan
通讯作者：
Wang, Xing-Huan