Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury.
Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury.
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DOI：
10.1001/archneurol.2010.342
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发表时间：
2011-01
影响因子：
--
通讯作者：
Diaz-Arrastia, Ramon
中科院分区：
文献类型：
--
作者：
de la Plata, Carlos D. Marquez;Garces, Juanita;Kojori, Ehsan Shokri;Grinnan, Jack;Krishnan, Kamini;Pidikiti, Rajesh;Spence, Jeffrey;Devous, Michael D., Sr.;Moore, Carol;McColl, Rodderick;Madden, Christopher;Diaz-Arrastia, Ramon
To examine the functional connectivity (fc) of hippocampal and selected frontal lobe circuits among patients with traumatic axonal injury (TAI). Echo-planar and high-resolution T1-weighted images were acquired using 3 Tesla scanners. Regions of interest (ROI) were drawn bilaterally for the hippocampus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC), and were used to extract time series data. BOLD data from each ROI were used as reference functions for correlating with all other brain voxels. Interhermispheric fc was assessed for each participant by correlating homologous regions using a Pearson correlation coefficient. Patient functional and neurocognitive outcomes were assessed approximately 6 months post-injury. Patients were recruited within days of their injury while in an inpatient traumatic brain injury unit. Imaging and neurocognitive assessments were conducted in an outpatient research facility. 25 consecutive patients with brain injuries consistent with TAI and acute subcortical white matter abnormalities were studied. Sixteen healthy volunteers of similar age and gender were recruited. Interhemispheric fc for each ROI was compared between patients and controls. Spatial patterns of fc were examined for each of the three ROIs. Connectivity measures were examined for associations with functional and neurocognitive outcomes. Patients showed significantly lower interhemispheric fc for the hippocampus and ACC. Healthy controls demonstrate stronger and more focused fc for hippocampi and ACC, and a more focused recruitment of the default mode network for the DLPFC ROI. The interhemispheric fc for the hippocampus was correlated to delayed recall of verbal information. Our findings suggest that traumatic axonal injury impacts interhemispheric neural activity, as patients with TAI show disrupted interhemipsheric fc. These results suggest more careful investigation of interhemisheric connectivity is warranted, as it demonstrated a modest association with outcome in chronic TBI.
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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Devous, Michael, Sr.
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Styles, P
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通讯作者：
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