Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study.
Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study.
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DOI：
10.1186/1471-2261-11-31
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发表时间：
2011-06-14
影响因子：
2.1
通讯作者：
Orentreich N
中科院分区：
文献类型：
--
作者：
Iribarren C;Phelps BH;Darbinian JA;McCluskey ER;Quesenberry CP;Hytopoulos E;Vogelman JH;Orentreich N
血管生成在心肌缺血时被上调。然而，目前评估循环血管生成生物标记物在预测急性心肌梗死(AMI)未来发病率方面的价值的数据有限。我们的目的是研究血管生成标志物的循环水平与男性和女性发生急性心肌梗死(AMI)的风险之间的关系。我们进行了一项病例对照研究(嵌套在北加州Kaiser Permanente接受护理的一大群人中)，包括695例急性心肌梗死患者和690名对照，分别在年龄、性别和种族/民族上进行匹配。急性心肌梗死患者血清血管内皮生长因子-A(血管内皮生长因子-A)和血管生成素-2(血管生成素-2)浓度的中位数均显著高于对照组(P<0.0001)。相比之下，内皮特异性受体酪氨酸激酶(Tie-2；14.2[3.7]vs.14.0[3.1]ng/mL；p=0.07)和血管生成素-1水平(Ang-1；33.1[13.6]vs.32.5[12.7]ng/mL；p=0.52)在病例对照状态下没有显著差异。在调整了受教育程度、高血压、糖尿病、吸烟、饮酒、体重指数、低密度脂蛋白、高密度脂蛋白、甘油三酯和C反应蛋白后，以Ang-2为Z分数每增加1个单位，患急性心肌梗死的几率增加1.17倍(95%可信区间，1.02至1.35)，血管紧张素-2的高四分位数相对于最低四分位数，患急性心肌梗死的几率增加1.63倍(95%可信区间，1.09至2.45)。我们的数据支持Ang-2作为独立于传统危险因素的急性心肌梗死发病生物标志物的作用。
Angiogenesis is up-regulated in myocardial ischemia. However, limited data exist assessing the value of circulating angiogenic biomarkers in predicting future incidence of acute myocardial infarction (AMI). Our aim was to examine the association between circulating levels of markers of angiogenesis with risk of incident acute myocardial infarction (AMI) in men and women. We performed a case-control study (nested within a large cohort of persons receiving care within Kaiser Permanente of Northern California) including 695 AMI cases and 690 controls individually matched on age, gender and race/ethnicity. Median [inter-quartile range] serum concentrations of vascular endothelial growth factor-A (VEGF-A; 260 [252] vs. 235 [224] pg/mL; p = 0.01) and angiopoietin-2 (Ang-2; 1.18 [0.66] vs. 1.05 [0.58] ng/mL; p < 0.0001) were significantly higher in AMI cases than in controls. By contrast, endothelium-specific receptor tyrosine kinase (Tie-2; 14.2 [3.7] vs. 14.0 [3.1] ng/mL; p = 0.07) and angiopoietin-1 levels (Ang-1; 33.1 [13.6] vs. 32.5 [12.7] ng/mL; p = 0.52) did not differ significantly by case-control status. After adjustment for educational attainment, hypertension, diabetes, smoking, alcohol consumption, body mass index, LDL-C, HDL-C, triglycerides and C-reactive protein, each increment of 1 unit of Ang-2 as a Z score was associated with 1.17-fold (95 percent confidence interval, 1.02 to 1.35) increased odds of AMI, and the upper quartile of Ang-2, relative to the lowest quartile, was associated with 1.63-fold (95 percent confidence interval, 1.09 to 2.45) increased odds of AMI. Our data support a role of Ang-2 as a biomarker of incident AMI independent of traditional risk factors.
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影响因子：
37.8
作者：
Lee, KW;Lip, GYH;Blann, AD
通讯作者：
Blann, AD
影响因子：
37.8
作者：
Moulton, KS;Heller, E;Folkman, J
通讯作者：
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DOI：
10.1152/ajpheart.00669.2004
发表时间：
2005-05-01
影响因子：
4.8
作者：
Matsunaga, T;Chilian, WM;March, K
通讯作者：
March, K
影响因子：
64.5
作者：
Suri, C;Jones, PF;Yancopoulos, GD
通讯作者：
Yancopoulos, GD
影响因子：
56.9
作者：
Maisonpierre, PC;Suri, C;Yancopoulos, GD
通讯作者：
Yancopoulos, GD