Investigating Virological, Immunological, and Pathological Avenues to Identify Potential Targets for Developing COVID-19 Treatment and Prevention Strategies.
Investigating Virological, Immunological, and Pathological Avenues to Identify Potential Targets for Developing COVID-19 Treatment and Prevention Strategies.
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DOI：
10.3390/vaccines8030443
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发表时间：
2020-08-06
期刊：
影响因子：
7.8
通讯作者：
Muhammad K
中科院分区：
文献类型：
--
作者：
Mahmood Z;Alrefai H;Hetta HF;A Kader H;Munawar N;Abdul Rahman S;Elshaer S;Batiha GE;Muhammad K
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新出现的冠状病毒，引起呼吸道疾病，通常称为COVID-19。这种新型冠状病毒在人与人之间传播，并在全球范围内造成严重的发病率和死亡率，导致目前的大流行。此外，疾病的严重程度因个体而异。研究COVID-19的病毒学及其临床表现背后的免疫学途径将有助于识别和设计有效的疫苗和潜在的治疗方法。在这篇综述中，我们探讨了COVID-19病毒学，免疫系统（先天性和适应性）在感染和控制病毒过程中的作用。最后，我们强调了疫苗的开发和免疫系统调节对潜在治疗干预的影响，以设计更好的治疗策略来指导未来的治疗。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus causing respiratory disease commonly known as COVID-19. This novel coronavirus transmits from human to human and has caused profound morbidity and mortality worldwide leading to the ongoing pandemic. Moreover, disease severity differs considerably from individual to individual. Investigating the virology of COVID-19 and immunological pathways underlying its clinical manifestations will enable the identification and design of effective vaccines and potential therapies. In this review, we explore COVID-19 virology, the contribution of the immune system (innate and adaptive) during infection and control of the virus. Finally, we highlight vaccine development and implications of immune system modulation for potential therapeutic interventions to design better therapeutic strategies to guide future cure.
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影响因子：
5.4
作者：
Chen, Jun;Lau, Yuk Fai;Subbarao, Kanta
通讯作者：
Subbarao, Kanta
影响因子：
10
作者：
Chu, CM;Cheng, VCC;Yuen, KY
通讯作者：
Yuen, KY
影响因子：
33.7
作者：
Choy, Ernest H.;De Benedetti, Fabrizio;Kishimoto, Tadamitsu
通讯作者：
Kishimoto, Tadamitsu
DOI：
10.1016/j.ijid.2013.12.003
发表时间：
2014-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Al-Tawfiq JA;Momattin H;Dib J;Memish ZA
通讯作者：
Memish ZA
影响因子：
2.8
作者：
Ahn DG;Shin HJ;Kim MH;Lee S;Kim HS;Myoung J;Kim BT;Kim SJ
通讯作者：
Kim SJ