Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats.
Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats.
复制标题
Zucker 大鼠脱氢表雄酮治疗后的代谢变化。
DOI：
10.1152/ajpendo.1984.246.2.e123
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Cleary
中科院分区：
文献类型：
--
作者：
A. Shepherd;M. Cleary
脱氢表雄酮（DHEA）是已知的葡萄糖-6-磷酸脱氢酶（G6PD）的非竞争性抑制剂。在本研究中，在瘦肉和肥胖的扎克大鼠中检查了慢性DHEA治疗对G6PD的影响以及其他几种参与脂质代谢的酶的影响。与未治疗的大鼠相比，在DHEA处理的大鼠中发现体重显着降低。在瘦大鼠中，DHEA治疗不会降低肝脏或脂肪组织G6PD和脂肪酸合成酶活性，而是增加了苹果酶的活性。在肥胖大鼠中，发现肝脏和脂肪组织G6PD和脂肪酸合成酶的活性减少。肥胖DHEA大鼠肝脏中的苹果酶活性增加，但在脂肪组织中没有增加。在瘦肉和肥胖的DHEA大鼠中，脂肪组织脂蛋白脂肪酶活性均降低。与对照肥胖大鼠相比，肥胖DHEA大鼠中的血清胰岛素也减少了。这些结果表明，G6PD的抑制可能不是DHEA抗肥料作用的作用机理。但是，肥胖大鼠中DHEA的代谢作用可能有助于其抗肥胖作用。
Dehydroepiandrosterone (DHEA) is a known noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD). In the present investigation, the effects of chronic DHEA treatment on G6PD and several other enzymes involved in lipid metabolism were examined in lean and obese Zucker rats. Significant decreases in body weight were found in DHEA-treated rats in comparison with nontreated rats. In lean rats, DHEA treatment did not decrease either liver or adipose tissue G6PD and fatty acid synthetase activity, but malic enzyme activity was increased. In obese rats, decreased liver and adipose tissue G6PD and fatty acid synthetase activities were found. Malic enzyme activity in liver of obese DHEA rats was increased but not in adipose tissue. Adipose tissue lipoprotein lipase activity was decreased in both lean and obese DHEA rats. Serum insulin in obese DHEA rats was also decreased compared with control obese rats. These results indicate that the inhibition of G6PD may not be the mechanism of action of the antiobesity effect of DHEA. However, the metabolic effects of DHEA seen in obese rats may contribute to its antiobesity action.
脱氢表雄酮和 16 α-溴-表雄酮：EB 病毒诱导的人类淋巴细胞转化的抑制剂。
影响因子：
4.7
作者：
Henderson,E;Schwartz,A;Pashko,L;Abou-Gharbia,M;Swern,D
通讯作者：
Swern,D