NeuroGrid: recording action potentials from the surface of the brain.
NeuroGrid: recording action potentials from the surface of the brain.
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DOI：
10.1038/nn.3905
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发表时间：
2015-02
影响因子：
25
通讯作者：
Buzsaki, Gyoergy
中科院分区：
文献类型：
--
作者：
Khodagholy, Dion;Gelinas, Jennifer N.;Thesen, Thomas;Doyle, Werner;Devinsky, Orrin;Malliaras, George G.;Buzsaki, Gyoergy
从神经网络记录动作电位的分辨率对于了解信息在大脑中是如何处理的至关重要。在这里，我们通过开发一种基于有机材料、超整合、生物兼容和可扩展的神经接口阵列来应对这一挑战，该阵列可以在不穿透大脑表面的情况下记录皮层浅层神经元的LFP和动作电位。具有中间神经元和锥体细胞特征的棘波被神经网的多个相邻电极同时获得，从而可以分离出大鼠的单个神经元。放电活动通过持续的脑振荡表现出一致的相位调制，并且在超过一周的记录中是稳定的。我们还记录了接受癫痫手术的患者术中LFP调节的棘波活动。神经网格构成了一种大规模、稳定地记录神经元棘波与局部群体突触活动相一致的有效方法，增强了对跨越时空尺度的神经过程的理解，并潜在地促进了脑部疾病的诊断和治疗。
Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultra-conformable, biocompatible and scalable neural interface array (the ‘NeuroGrid’) that can record both LFP and action potentials from superficial cortical neurons without penetrating the brain surface. Spikes with features of interneurons and pyramidal cells were simultaneously acquired by multiple neighboring electrodes of the NeuroGrid, allowing for isolation of putative single neurons in rats. Spiking activity demonstrated consistent phase modulation by ongoing brain oscillations and was stable in recordings exceeding one week. We also recorded LFP-modulated spiking activity intra-operatively in patients undergoing epilepsy surgery. The NeuroGrid constitutes an effective method for large-scale, stable recording of neuronal spikes in concert with local population synaptic activity, enhancing comprehension of neural processes across spatiotemporal scales and potentially facilitating diagnosis and therapy for brain disorders.
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影响因子：
41.2
作者：
通讯作者：
--
影响因子：
29.4
作者：
Khodagholy, Dion;Doublet, Thomas;Malliaras, George G.
通讯作者：
Malliaras, George G.
DOI：
10.1523/jneurosci.2187-09.2009
发表时间：
2009-08-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jacobs J;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
25
作者：
Lee, Soohyun;Kruglikov, Illya;Huang, Z. Josh;Fishell, Gord;Rudy, Bernardo
通讯作者：
Rudy, Bernardo
影响因子：
14.5
作者：
Besson, Pierre;Andermann, Frederick;Bernasconi, Andrea
通讯作者：
Bernasconi, Andrea