Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.
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能够与生物组织柔软的曲线表面紧密、无创整合的电子器件为疾病诊断和治疗以及改进脑机接口提供了重要机遇。本文介绍了一种生物接口系统的材料策略，该系统依赖于由丝素蛋白生物可吸收基底支撑的超薄电子器件。将此类器件安装在组织上，然后让丝素溶解和吸收，会在生物/非生物界面由毛细作用力驱动一个自发的、共形的包裹过程。电子器件的特殊网格设计和超薄形态确保了对组织的应力最小，并且即使对于复杂的曲线表面也能实现高度共形覆盖，这已通过实验和理论研究得到证实。在猫科动物模型上进行的体内神经映射实验说明了这类技术的一种使用模式。这些概念为可植入或手术设备提供了新的功能。
Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain-machine interfaces. This paper describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable or surgical devices.
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