Prostate histotripsy: evaluation of prostatic urethral treatment parameters in a canine model.
Prostate histotripsy: evaluation of prostatic urethral treatment parameters in a canine model.
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DOI：
10.1111/bju.12333
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发表时间：
2014-03
影响因子：
4.5
通讯作者：
Roberts WW
中科院分区：
文献类型：
--
作者：
Schade GR;Styn NR;Ives KA;Hall TL;Roberts WW
旨在评估组织碎石术治疗参数（脉冲数和脉冲重复频率[PRF]）对组织碎石术诱导前列腺尿道均质化效率的影响。共进行了34次经腹前列腺组织摧毁术治疗，沿着垂直平面穿过21只犬受试者的前列腺尿道。采用1）具有固定PRF的递增脉冲数或2）具有不同PRF的固定脉冲数进行前列腺组织碎石术。在组织破坏后14天内，通过内窥镜评价尿道均质化的发展，并通过组织学证实。在组织碎石术的14天内，接受12.5k、25 k、50 k和100 k脉冲/mm治疗路径（以500 Hz PRF递送）的受试者中分别有50%、83%、83%和100%发生前列腺尿道崩解。在组织碎石术治疗的24小时内，所有受试者都需要每mm输送100 k脉冲以实现尿道崩解。将组织破坏PRF从50 Hz增加到500 Hz再增加到2，000 Hz，同时施加恒定剂量的25 k脉冲/mm治疗，与尿道解体率增加相关（14天时分别为50% vs 75% vs 100%）。增加组织碎石脉冲的数量和/或增加应用于尿道的组织碎石治疗的PRF可以改善犬模型中前列腺尿道崩解的速率和效率。这种理解将有助于在人类试验中开发前列腺组织破坏术治疗BPH的治疗策略。
To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenization of the prostatic urethra. A total of 34 transabdominal prostate histotripsy treatments were applied along a perpendicular plane traversing the prostatic urethra of 21 canine subjects. Prostate histotripsy was applied with 1) escalating pulse number with fixed PRF or 2) at fixed pulse number with varying PRFs. The development of urethral homognization within 14 days of histotripsy was evaluated endoscopically and confirmed histologically. Within 14 days of histotripsy 50%, 83%, 83%, and 100% of subjects receiving 12.5k, 25k, 50k, and 100k pulses per mm of treatment path (delivered at 500Hz PRF), respectively developed prostatic urethral disintegration. Delivery of 100k pulses per mm was required to achieve urethral disintegration in all subjects within 24 hours of histotripsy treatment. Increasing histotripsy PRF from 50Hz to 500Hz to 2,000Hz while applying a constant dose of 25k pulses per mm treatment was associated with increased rate of urethral disintegration (50% vs 75% vs 100% at 14 days, respectively). Increasing the number of histotripsy pulses and/or increasing the PRF of histotripsy treatment applied to the urethra may improve the rate and efficiency of prostatic urethral disintegration in the canine model. This understanding will aid in the development of treatment strategies for prostate histotripsy for BPH in human trials.
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影响因子：
2.4
作者：
Xu, Z;Fowlkes, JB;Cain, CA
通讯作者：
Cain, CA
DOI：
10.1109/tuffc.2003.1244746
发表时间：
2003-10-01
影响因子：
3.6
作者：
Tran, BC;Seo, J;Cain, CA
通讯作者：
Cain, CA
影响因子：
23.4
作者：
Crouzet, Sebastien;Rebillard, Xavier;Gelet, Albert
通讯作者：
Gelet, Albert
影响因子：
2.1
作者：
Hall, Timothy L.;Hempel, Christopher R.;Wojno, Kirk;Xu, Zhen;Cain, Charles A.;Roberts, William W.
通讯作者：
Roberts, William W.
影响因子：
6.6
作者：
Ahmed, H. U.;Freeman, A.;Emberton, M.
通讯作者：
Emberton, M.