Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
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DOI：
10.1186/cc2872
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发表时间：
2004-08
期刊：
影响因子：
--
通讯作者：
Acute Dialysis Quality Initiative workgroup
中科院分区：
文献类型：
--
作者：
Bellomo R;Ronco C;Kellum JA;Mehta RL;Palevsky P;Acute Dialysis Quality Initiative workgroup
目前对危重患者的急性肾衰竭（ARF）尚无一致的定义。文献中使用了30多个不同的定义，造成了很大的混乱，难以进行比较。同样，关于ARF动物模型的有效性和临床相关性也存在激烈的争论;关于液体管理和该领域新干预措施试验终点的选择;以及如何使用信息技术来协助这一过程。因此，我们试图审查现有的证据，提出建议，并划定未来研究的关键问题。我们使用Medline和PubMed检索对文献进行了系统回顾。我们确定了一系列关键问题，并召开了为期两天的共识会议，通过一系列交替的分组会议和全体会议编写总结声明。在这些会议中，我们确定了支持证据，并为未来的研究提出了建议和/或方向。我们在47个问题上达成了足够的共识，可以提出建议。重要的是，我们能够为ARF制定一个共识定义。在某些情况下，还可以为今后的调查提出有益的协商一致建议。我们提出了一个总结的结果。(Full六个工作组的研究结果的版本可在因特网上获得，网址为：）尽管数据有限，但对于指导定义ARF的共识建议的发展所需的生理和临床原则、动物模型的选择、监测液体治疗的方法、试验的生理和临床终点的选择以及信息技术的可能作用，存在广泛的共识领域。
There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on how information technology can be used to assist this process. Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies. We undertook a systematic review of the literature using Medline and PubMed searches. We determined a list of key questions and convened a 2-day consensus conference to develop summary statements via a series of alternating breakout and plenary sessions. In these sessions, we identified supporting evidence and generated recommendations and/or directions for future research. We found sufficient consensus on 47 questions to allow the development of recommendations. Importantly, we were able to develop a consensus definition for ARF. In some cases it was also possible to issue useful consensus recommendations for future investigations. We present a summary of the findings. (Full versions of the six workgroups' findings are available on the internet at ) Despite limited data, broad areas of consensus exist for the physiological and clinical principles needed to guide the development of consensus recommendations for defining ARF, selection of animal models, methods of monitoring fluid therapy, choice of physiological and clinical end-points for trials, and the possible role of information technology.
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