Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System.
Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System.
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DOI：
10.1016/j.tins.2016.03.005
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发表时间：
2016-06
影响因子：
15.9
通讯作者：
Stanley ER
中科院分区：
文献类型：
--
作者：
Chitu V;Gokhan Ş;Nandi S;Mehler MF;Stanley ER
集落刺激因子 1 受体 (CSF-1R) 激酶调节组织巨噬细胞稳态、破骨细胞生成和潘氏细胞发育。然而，最近对小鼠的研究表明，CSF-1R信号直接控制小胶质细胞的发育和维持，并且细胞自主调节神经元分化和存活。虽然 CSF-1R 关联配体 CSF-1 和白细胞介素 34 (IL-34) 竞争与 CSF-1R 的结合，但成熟神经元以很大程度上不重叠的方式表达它们。最近发现与 CSF-1R 失活突变相关的显性遗传、成人发病、进行性痴呆强调了 CSF-1R 信号在大脑中的重要性。我们回顾了 CSF-1R 及其配体在小胶质细胞和神经发育和功能中的作用，以及它们与我们理解神经退行性疾病的相关性。
The colony stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in mice have revealed that CSF-1R signaling directly controls the development and maintenance of microglia, and cell autonomously regulates neuronal differentiation and survival. While the CSF-1R-cognate ligands, CSF-1 and interleukin-34 (IL-34), compete for binding to the CSF-1R, they are expressed in a largely non-overlapping manner by mature neurons. The recent identification of a dominantly inherited, adult-onset, progressive dementia associated with inactivating mutations in the CSF-1R highlights the importance of CSF-1R signaling in the brain. We review the roles of the CSF-1R and its ligands in microglial and neural development and function, and their relevance to our understanding of neurodegenerative disease.
DOI：
10.1083/jcb.77.1.35
发表时间：
1978-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Johnson GR;Burgess AW
通讯作者：
Burgess AW