β-Adrenergically mediated thermogenic and heart rate responses: Effect of obesity and weight loss
β-Adrenergically mediated thermogenic and heart rate responses: Effect of obesity and weight loss
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β-肾上腺素能介导的产热和心率反应：肥胖和减肥的影响
DOI：
10.1016/0026-0495(95)90061-6
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发表时间：
1995
影响因子：
9.8
通讯作者：
W. Saris
中科院分区：
文献类型：
--
作者：
E. Blaak;M. A. Baak;A. Kester;W. Saris
采用部分回归分析的方法，对30名体脂范围较大的男性和16名肥胖男性减肥后β-肾上腺素介导的发热和心率(HR)反应进行了评估，这些反应是通过静脉注射β-激动剂异丙肾上腺素来评估的。在肥胖者中，β-肾上腺素介导的生热作用(开路通风罩系统)被钝化，这反映在体脂百分比(静水称重)与血浆ISO浓度之间存在显著的正相关，以使静息能量消耗(EE)增加15%(P<；.001)。β-肾上腺素介导的心率反应的幅度与基础血浆去甲肾上腺素(NE)浓度呈负相关(P<；.001)。体重减轻导致肥胖者的生热反应和心率反应显著增加。此外，体重减轻导致的生热反应增加与生热反应的大小呈负相关(P<；.01)，与初始体脂百分比呈正相关(P<；.05)。体重减轻引起的HR反应增加与基础NE的降低(P<；.01)和体脂百分比的变化(P<；.05)呈正相关。总而言之，肥胖程度与β-肾上腺素介导的产热作用的大小呈负相关，而HR反应仅与基础NE有关。由于体重减轻导致生热反应显著增加，钝化的β-肾上腺素介导的生热反应似乎不是导致肥胖的主要因素。
β-Adrenergically mediated thermogenic and heart rate (HR) responses, as assessed by stepwise intravenous infusion of the β-agonist isoprenaline (ISO), were evaluated by partial regression analysis in a group of men with a wide range of body fat (n = 30) and in a subgroup of 16 obese men after weight loss. β-Adrenergically mediated thermogenesis (open-circuit ventilated-hood system) was blunted in obese subjects, as reflected by a significant positive correlation between percent body fat (hydrostatic weighing) and the plasma ISO concentration needed to increase resting energy expenditure (EE) by 15% (P < .001). The magnitude of the β-adrenergically mediated HR response was (negatively) associated with the basal plasma norepinephrine (NE) concentration (P < .001). Weight reduction resulted in a significant increase in thermogenic and HR responses in obese subjects. Furthermore, the increase in thermogenic response as a result of weight loss was negatively related to the magnitude of thermogenic response (P < .01) and positively related to the initial percent body fat (P < .05). The increase in HR response as a result of weight loss was positively related to the decrease in basal NE (P < .01) and the change in percent body fat (P < .05). In conclusion, the degree of adiposity was shown to be negatively related to the magnitude of β-adrenergically mediated thermogenesis, whereas the HR response was merely related to basal NE. Since weight loss resulted in a significant increase in the thermogenic response, the blunted β-adrenergically mediated thermogenesis does not seem to be a primary factor contributing to the development of obesity.
人类肾上腺素能受体：直接识别、生理调节和临床改变。
DOI：
10.1056/nejm198207013070104
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Motulsky,HJ;Insel,PA
通讯作者：
Insel,PA