Serum retinol and subsequent risk of cancer.
Serum retinol and subsequent risk of cancer.
复制标题
血清视黄醇和随后的癌症风险。
作者：
N. Wald;J. Boreham;A. Bailey
在一项前瞻性研究中，约有22 000名男子参加了健康人筛查中心，收集并储存了血清样本。在储存的血清样品中测量视黄醇的浓度，这些血清样品来自随后被告知患有癌症的227名男性和来自454名未受影响的对照组，这些对照组与血清样品的年龄、吸烟史和储存时间相匹配。在采集血液后一年内发生癌症的癌症受试者的平均血清视黄醇浓度显著低于其匹配对照组的平均浓度（分别为641和722微克l-1，P <0.001）。对于那些在血液采集后1 - 2年发生癌症的受试者，差异较小（分别为650和701微克l-1，P <0.01）。对于那些在血液采集后三年或更长时间内患上癌症的受试者，其平均视黄醇水平高于对照组，尽管在统计学上并不显著（分别为694和663微克l-1）。这些研究结果表明，血清视黄醇与先前观察到的癌症风险之间的负相关是由于低血清视黄醇是癌症的代谢结果，而不是癌症的前兆。
In a prospective study of about 22,000 men attending a well person screening centre, serum samples were collected and stored. The concentration of retinol was measured in the stored serum samples from 227 men subsequently notified as having cancer and from 454 unaffected controls, matched for age, smoking history and duration of storage of the serum samples. The mean serum retinol concentration of the cancer subjects who developed cancer before the elapse of one year since the time blood was collected was significantly lower than the mean concentration of their matched controls (641 and 722 micrograms l-1 respectively, P less than 0.001). For subjects whose cancer developed one to two years after blood had been collected, the difference was less (650 and 701 micrograms l-1 respectively, P less than 0.01). For subjects whose cancer developed three or more years after blood was collected, the mean retinol level was higher than in their controls, although not statistically significantly so (694 and 663 micrograms l-1 respectively). These findings suggest that the inverse association between serum retinol and risk of cancer that was previously observed was due to low serum retinol being a metabolic consequence of cancer rather than a precursor of cancer.
夏威夷日本血统男性的血清维生素水平和特定部位患癌症的风险。
影响因子：
11.2
作者：
Nomura,AM;Stemmermann,GN;Heilbrun,LK;Salkeld,RM;Vuilleumier,JP
通讯作者：
Vuilleumier,JP
血清视黄醇和视黄醇结合蛋白水平不能预测随后的肺癌。
影响因子：
5
作者：
Friedman,GD;Blaner,WS;Goodman,DS;Vogelman,JH;Brind,JL;Hoover,R;Fireman,BH;Orentreich,N
通讯作者：
Orentreich,N