The emergence of phox-ER stress induced immunogenic apoptosis.
The emergence of phox-ER stress induced immunogenic apoptosis.
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DOI:
10.4161/onci.19750
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发表时间:
2012-08-01
期刊:
影响因子:
7.2
通讯作者:
Agostinis P
中科院分区:
文献类型:
--
作者:
Garg AD;Krysko DV;Vandenabeele P;Agostinis P
Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved “core” functions (e.g., PERK/PI3K-based modulation of secretory trafficking) rather than “private” ones (caspase-8 and eIF2α-phosphorylation) engaged by other IA inducers.
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