Chemotherapy-induced peripheral neuropathy: A current review.
Chemotherapy-induced peripheral neuropathy: A current review.
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DOI：
10.1002/ana.24951
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发表时间：
2017-06
影响因子：
11.2
通讯作者：
Windebank AJ
中科院分区：
文献类型：
--
作者：
Staff NP;Grisold A;Grisold W;Windebank AJ
化疗诱导的周围神经病变（CIPN）是接受癌症治疗的患者经历的常见剂量限制性副作用。大约30-40%接受神经毒性化疗的患者会发生CIPN，并且患者之间的严重程度存在相当大的差异。它通常以感觉为主，伴有疼痛，并可导致幸存者长期发病。随着癌症生存率的持续提高，CIPN晚期效应的患病率和负担可能会增加。在这篇综述中，我们讨论了癌症患者周围神经病变的治疗方法，并讨论了特定神经毒性化疗药物的临床表型和病理机制。
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect experienced by patients receiving treatment for cancer. Approximately 30–40% of patients treated with neurotoxic chemotherapy will develop CIPN and there is considerable variability in its severity between patients. It is often sensory-predominant with pain and can lead to long-term morbidity in survivors. The prevalence and burden of CIPN late effects will likely increase as cancer survival rates continue to improve. In this review, we discuss the approach to peripheral neuropathy in patients with cancer and address the clinical phenotypes and pathomechanisms of specific neurotoxic chemotherapeutic agents.
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影响因子：
11.2
作者：
Beutler, Andreas S.;Kulkarni, Amit A.;Kanwar, Rahul;Klein, Christopher J.;Therneau, Terry M.;Qin, Rui;Banck, Michaela S.;Boora, Ganesh K.;Ruddy, Kathryn J.;Wu, Yanhong;Smalley, Regenia L.;Cunningham, Julie M.;Le-Lindqwister, Nguyet Anh;Beyerlein, Peter;Schroth, Gary P.;Windebank, Anthony J.;Zuechner, Stephan;Loprinzi, Charles L.
通讯作者：
Loprinzi, Charles L.
影响因子：
9.9
作者：
AMATO, AA;BAROHN, RJ;MENDELL, JR
通讯作者：
MENDELL, JR
影响因子：
3.1
作者：
Bentzen, Anne Gry;Balteskard, Lise;Guren, Marianne Gronlie
通讯作者：
Guren, Marianne Gronlie
影响因子：
3.8
作者：
Cavaletti, G;Jann, S;Giussani, G
通讯作者：
Giussani, G
影响因子：
4.4
作者：
Boora GK;Kulkarni AA;Kanwar R;Beyerlein P;Qin R;Banck MS;Ruddy KJ;Pleticha J;Lynch CA;Behrens RJ;Züchner S;Loprinzi CL;Beutler AS
通讯作者：
Beutler AS