Small-molecule pheromones and hormones controlling nematode development.
Small-molecule pheromones and hormones controlling nematode development.
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DOI：
10.1038/nchembio.2356
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发表时间：
2017-05-17
影响因子：
14.8
通讯作者：
Butcher RA
中科院分区：
文献类型：
--
作者：
Butcher RA
影响秀丽隐杆线虫发育的小分子信号的存在已经知道了几十年，但只是在最近几年才建立了这些信号的化学结构。这些信号的识别使得这些小分子和C.它们不仅影响发育，还影响新陈代谢、生育力和寿命。在这些重要发现的推动下，并在比较代谢组学和NMR光谱学的最新进展的帮助下，线虫化学领域有可能在未来几年内急剧扩大。这篇评论将集中在小分子信息素和激素的影响线虫的生命周期中的发育事件（ascarosides，dafachronic酸，和nemamides），将涵盖更多的最近的工作有关这些信号的生物合成，并将探讨如何发现这些信号正在改变我们的理解线虫的发育和生理。
The existence of small-molecule signals that influence development in Caenorhabditis elegans has been known for several decades, but only in recent years have the chemical structures of several of these signals been established. The identification of these signals has enabled connections to be made between these small molecules and fundamental signaling pathways in C. elegans that influence not only development, but also in metabolism, fertility, and lifespan. Spurred by these important discoveries and aided by recent advances in comparative metabolomics and NMR spectroscopy, the field of nematode chemistry has the potential to expand dramatically in the coming years. This review will focus on small-molecule pheromones and hormones that influence developmental events in the nematode life cycle (ascarosides, dafachronic acids, and nemamides), will cover more recent work regarding the biosynthesis of these signals, and will explore how the discovery of these signals is transforming our understanding of nematode development and physiology.
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DOI：
10.1016/0014-4894(57)90037-1
发表时间：
1957-01-01
期刊：
EXPTL PARASITOL
影响因子：
--
作者：
FAIRBAIRN, DONALD
通讯作者：
FAIRBAIRN, DONALD
影响因子：
9.2
作者：
Choe, Andrea;von Reuss, Stephan H.;Kogan, Dima;Gasser, Robin B.;Platzer, Edward G.;Schroeder, Frank C.;Sternberg, Paul W.
通讯作者：
Sternberg, Paul W.
影响因子：
9.2
作者：
Erkut, Cihan;Penkov, Sider;Kurzchalia, Teymuras V.
通讯作者：
Kurzchalia, Teymuras V.
影响因子：
2.7
作者：
CASSADA, RC;RUSSELL, RL
通讯作者：
RUSSELL, RL
影响因子：
64.8
作者：
Bento, Gilberto;Ogawa, Akira;Sommer, Ralf J.
通讯作者：
Sommer, Ralf J.