Demonstration that a new flow sensor can operate in the clinical range for cerebrospinal fluid flow.
Demonstration that a new flow sensor can operate in the clinical range for cerebrospinal fluid flow.
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证明新型流量传感器可以在脑脊液流量的临床范围内运行。
DOI：
10.1016/j.sna.2015.08.023
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Farrow,ReginaldC
中科院分区：
文献类型：
--
作者：
Raj,Rahul;Lakshmanan,Shanmugamurthy;Apigo,David;Kanwal,Alokik;Liu,Sheng;Russell,Thomas;Madsen,JosephR;Thomas,GordonA;Farrow,ReginaldC
已经制造并测试了一种流量传感器，该传感器能够测量脑脊液在小于4ml /h至大于100ml /h范围内的慢流特性。这种传感器适合长期植入，因为它使用无线外部光谱仪来测量被动皮下成分。传感器是压力敏感电容器，在5 pF范围内，在大气压下具有气隙。每个电容器与一个电感串联，以提供随流量变化的谐振频率。在恒定流量下，系统在一个月内稳定，漂移< 0.3 mL/h。在变流量V˙时，谐振频率f 0在200 - 400mhz范围内，与V˙呈二阶多项式关系。对于该传感器系统，测量f0的不确定度为30 kHz，对应于测量流量的灵敏度Δ V˙= 0.6 mL/hr。压力高达20厘米的h2o相对于环境压力也被测量。提出了一种可植入的双电容测量系统，该系统可以完全补偿所有静水压力。对于双电容，临床范围内系统变化的其他来源，如温度和环境压力，小于我们的灵敏度，我们描述了一种校准方法，应该在很长一段时间内保持临床有用的准确性。
A flow sensor has been fabricated and tested that is capable of measuring the slow flow characteristic of the cerebrospinal fluid in the range from less than 4 mL/h to above 100 mL/h. This sensor is suitable for long-term implantation because it uses a wireless external spectrometer to measure passive subcutaneous components. The sensors are pressure-sensitive capacitors, in the range of 5 pF with an air gap at atmospheric pressure. Each capacitor is in series with an inductor to provide a resonant frequency that varies with flow rate. At constant flow, the system is steady with drift< 0.3 mL/h over a month. At variable flow rate, V˙, the resonant frequency, f 0, which is in the 200–400 MHz range, follows a second order polynomial with respect to V˙. For this sensor system the uncertainty in measuring f 0 is 30 kHz which corresponds to a sensitivity in measuring flow of Δ V˙= 0.6 mL/hr. Pressures up to 20 cm H 2 O relative to ambient pressure were also measured. An implantable twin capacitor system is proposed that can measure flow, which is fully compensated for all hydrostatic pressures. For twin capacitors, other sources of systematic variation within clinical range, such as temperature and ambient pressure, are smaller than our sensitivity and we delineate a calibration method that should maintain clinically useful accuracy over long times.
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